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A mid-infrared attenuated total reflection (ATR) spectroscopy system employing hollow optical fibers and a trapezoidal multi-reflection ATR prism has been developed to measure blood glucose levels. Using a multi-reflection prism brought about higher sensitivity, and the flat and wide contact surface of the prism resulted in higher measurement reproducibility. In the analysis of in vivo measurement of human inner lip mucosa, clear signatures of glucose were evident in difference spectra between the fasting stage and higher glucose levels. By focusing an absorption peak at 1155 cm−1 that originates from the pyranose ring structure of glucose, a calibration plot with the measurement errors less than 20% was obtained.
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