Summary
International Symposium on Nonlinear Theory and its Applications
2017
Session Number:B1L-B-2
Session:
Number:B1L-B-2-2
Mathematical Model of TRPM2 Activation in Pancreatic β-cells
Kantaro Fujiwara, Hiroyasu Ando, Tohru Ikeguchi, Masashi Yoshida, Masafumi Kakei,
pp.387-390
Publication Date:2017/12/4
Online ISSN:2188-5079
DOI:10.34385/proc.29.B1L-B-2-2
Summary:
In pancreatic β-cells, glucose-induced membrane depolarization is mainly realized by closure of ATP-sensitive K+ channel, followed by activation of voltage-dependent Ca2+ channels. Recently, the importance of TRPM2 channel has been reported by physiological experiment. Activation of the TRPM2 channel works in concert with closure of ATP-sensitive K+ channel to effectively induce membrane depolarization to initiate insulin secretion. However, its mechanism is still unclear. In this study, we construct a mathematical model of pancreatic β-cell model including TRPM2 channel. By comparing its membrane potential characteristics with the results obtained physiologically, the plausibility of our model is discussed. The effect of TRPM2 channel is also investigated theoretically.