Summary
International Symposium on Nonlinear Theory and its Applications
2008
Session Number:B3L-B
Session:
Number:B3L-B5
Assessing the local stability of action potential propagation in cardiac tissue
Enno de Lange, Jan P. Kucera,
pp.-
Publication Date:2008/9/7
Online ISSN:2188-5079
Summary:
We devised a method to assess the local stability of action potential propagation in cardiac tissue using coupled iterated maps of propagation velocity and action potential duration. The method is illustrated using simulations of propagation in chains of Luo-Rudy cell models and electrophysiological recordings from patterned strands of cultured neonatal rat ventricular myocytes. We de-stabilize conduction by decreasing extracellular potassium concentration. A first-order linear model gives a good description of the observed dynamics for both the control and the low extracellular potassium situation.