Summary
the 2014 International Symposium on Nonlinear Theory and its Applications
2014
Session Number:C1L-C
Session:
Number:C1L-C3
An approach to the biological pacemaker engineering based on the bifurcation analysis of a human ventricular cell model
Yoshiki Ogawa, Shinji Doi,
pp.427-430
Publication Date:2014/9/14
Online ISSN:2188-5079
Summary:
Electronic pacemakers play an important role in the treatment of bradyarrhythmia. Recently, different strategies to initiate pacemaker activity by genetic modification of ionic currents across the cell membrane were developed. These new approaches are called biological pacemaker (BP) engineering. Recent studies on the creation of the BP using mathematical cell models have revealed the mechanism of induction of pacemaker activity and pacemaking current. However, these studies have used the models of a guinea pig ventricular myocyte. In this paper, we use the reduced ten Tusscher-Noble-Noble- Panfilov (TNNP) model of human ventricular myocytes. We analyze the bifurcation structure of the model by varying conductances of ion channels, and examine the method to create a BP. The results show that the human ventricular myocytes can be converted to cardiac pacemaker by suppression of the inward rectifier potassium current.