Summary
International Symposium on Nonlinear Theory and Its Applications
2022
Session Number:A4L-E
Session:
Number:A4L-E-03
Analysis of Arrhythmias Generation in a Mathematical Ventricular Cell Model
Ryosuke Fujiwara , Hiroyuki Kitajima,
pp.151-154
Publication Date:12/12/2022
Online ISSN:2188-5079
Summary:
We investigated the occurrence of early and delayed afterdepolarization (EAD and DAD) by varying two parameters (L-type calcium current conductance and intracellular sodium concentration) in a mathematical model (Shannon model). As a result, we obtained that the conductances of the L-type calcium current and intracellular concentration of sodium are keys to generation of EADs and DADs. We identified the parameter regions in which EADs, DADs, fibrillations and tachycardias occur.