Summary
International Symposium on Nonlinear Theory and its Applications
2017
Session Number:B1L-B-1
Session:
Number:B1L-B-1-1
Efficient Control of Theta Traveling Waves by Synchronized Inhibition Through Gap Junctions and GABAergic Connections in a Hippocampal CA3 Model
Toshikazu Samura, Yutaka Sakai, Hatsuo Hayashi, Takeshi Aihara,
pp.367-370
Publication Date:2017/12/4
Online ISSN:2188-5079
DOI:10.34385/proc.29.B1L-B-1-1
Summary:
It has been demonstrated that directional theta traveling waves are organized in a biophysical hippocampal CA3 recurrent network model. Inhibitions play an important role in organizing traveling waves. In the hippocampus, both gap junctions and GABAergic connections exist between interneurons and affect interactions between interneurons. We evaluated the role of the interaction through both types of connections and found that the connectivity enables a hippocampal CA3 recurrent network model to suppress the activities of interneurons but to synchronize interneurons. Although inhibitions are reduced, synchronized inhibitions are sufficient to control directional traveling waves. These results suggest that the interaction between interneurons through gap junctions and GABAergic connections contribute to efficient control of theta traveling waves in the hippocampus.