会議略称 NOLTA
国際会議名称 Proceedings of the 2012 International Symposium on Nonlinear Theory and its Applications
開催年 2012
セッション番号 C1L-B
セッション名 Special Session: Excitability and Dynamics in Neuronal Networks: from Cultures to the Brain
講演番号 547
開催日(セッション) 2012/10/25
タイトル The role of connectivity and noise in the emergence of spontaneous activity in cultured neuronal networks
著者名 Javier G. OrlandiEnrique Alvarez-LacalleSara TellerJaume CasademuntJordi Soriano
Vol.1, No.547, pp.547-550
要旨 Cultured neurons in vitro quickly connect to one another to establish a spontaneously active network within a week. The resulting neuronal network is characterized by a combination of excitatory and inhibitory integrate-and-fire units coupled through synaptic connections, and that interact in a highly nonlinear manner. The nonlinear behavior emerges from the dynamics of both the neurons' membrane potential and synaptic transmission, together with intrinsic biological noise. These ingredients give rise to a rich repertoire of phenomena that are still poorly understood, including periodic spontaneous activity, avalanches, propagation of activity fronts, and synchronization. Here we describe some experimental results on spontaneous activity in cultures, and elaborate on theoretical models that describe its initiation and maintenance.
DOI 10.15248/proc.1.547
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