Summary

国際会議講演論文
会議略称 NOLTA
国際会議名称 Proceedings of the 2012 International Symposium on Nonlinear Theory and its Applications
開催年 2012
セッション番号 C1L-A
セッション名 Special Session: Nonlinear Data Analysis for Complex Systems
講演番号 543
開催日(セッション) 2012/10/25
タイトル Causality analysis in epileptic seizure genesis
著者名 Ryosuke HosakaShin-ichiro OsawaMasaki IwasakiYoshiya MatsuzakaHiroshi TomitaToru IshizukaEriko SuganoEiichi OkumuraHiromu YawoNobukazu NakasatoTeiji TominagaHajime Mushiake
Vo.No.
開始ページ.終了ページ
Vol.1, No.543, pp.543-546
種別
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キーワード
公開日
要旨 Epileptic seizure is a paroxysmal and self-limited phenomenon characterized by abnormal hyper-synchrony of large population of neurons. No studies have investigated network dynamics of epileptic seizures in the hippocampus in vivo, because no good animal models have been available to study seizures in vivo with high reproducibility. We used optogenetic techniques to perturb normal hippocampal network to induce epileptic seizures. This enables us to induce epileptic seizures in the hippocampus with high reproducibility, and permit simultaneous neurophysiological monitoring. Using this model, we revealed state changes along the longitudinal hippocampus during seizure genesis and termination.
DOI 10.15248/proc.1.543
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