| Conference Short | NOLTA |
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| Conference Name | Proceedings of the 2012 International Symposium on Nonlinear Theory and its Applications |
| Conference Year | 2012 |
| Session Number | C1L-A |
| Session Name | Special Session: Nonlinear Data Analysis for Complex Systems |
| Number | 543 |
| Session Date | 2012/10/25 |
| Title | Causality analysis in epileptic seizure genesis |
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| Author | Ryosuke Hosaka, Shin-ichiro Osawa, Masaki Iwasaki, Yoshiya Matsuzaka, Hiroshi Tomita, Toru Ishizuka, Eriko Sugano, Eiichi Okumura, Hiromu Yawo, Nobukazu Nakasato, Teiji Tominaga, Hajime Mushiake, |
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Vol.1, No.543, pp.543-546 |
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| Abstract | Epileptic seizure is a paroxysmal and self-limited phenomenon characterized by abnormal hyper-synchrony of large population of neurons. No studies have investigated network dynamics of epileptic seizures in the hippocampus in vivo, because no good animal models have been available to study seizures in vivo with high reproducibility. We used optogenetic techniques to perturb normal hippocampal network to induce epileptic seizures. This enables us to induce epileptic seizures in the hippocampus with high reproducibility, and permit simultaneous neurophysiological monitoring. Using this model, we revealed state changes along the longitudinal hippocampus during seizure genesis and termination. |
| DOI | 10.15248/proc.1.543 |
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