Summary
the 2014 International Symposium on Nonlinear Theory and its Applications
2014
Session Number:C3L-C
Session:
Number:C3L-C2
Comparing the Efficiency of DBS Patterns in a Stochastic Dynamical Model
Sofia D. Karamintziou, George L. Tsirogiannis, Pantelis G. Stathis, George A. Tagaris, Efstathios J. Boviatsis, Damianos E. Sakas, Konstantina S. Nikita,
pp.594-597
Publication Date:2014/9/14
Online ISSN:2188-5079
Summary:
A stochastic phase model is fitted to 216 microelectrode recordings (MERs), acquired during 18 surgical interventions in patients with Parkinson’s disease (PD), in order to comparatively simulate the desynchronizing effect of regular (130 Hz) versus nonregular patterns of stimulation with the same mean frequency and increasing degrees of temporal variability. We demonstrate that non-regular patterns of stimulation displaying a minimum variability of 70-80% yield a significantly higher Lyapunov exponent compared with regular stimulation, at the 5% significance level. The stochastic model points to the prominent role of nonregular stimulation patterns in the therapeutic outcome of deep brain stimulation (DBS).