Summary
2011 International Symposium on Nonlinear Theory and Its Applications
2011
Session Number:B2L-A
Session:
Number:B2L-A4
Modified Luo-Rudy model and its bifurcation analysis for suppressing alternans
Hiroyuki Kitajima, Toru Yazawa,
pp.390-393
Publication Date:2011/9/4
Online ISSN:2188-5079
DOI:10.34385/proc.45.B2L-A4
PDF download (422.2KB)
Summary:
Electrical alternans is alternating amplitude from beat to beat in the action potential for the cardiac cell. It has been associated with ventricular arrhythmias in many clinical studies, however, its dynamical mechanisms remain unknown. The reason is that we do not have simple network models of the heart system. Recently, Yazawa clarified network structure of the heart and the central nerve system. In this study, we construct a simple model of the heart system based on Yazawa’s experimental data. Using this model, we clarify that the reversal potential for the time-independent potassium current plays a key role of generating alternans. This result indicates that if the cardiac cell has some problems such as channelopathies, then there is great risk of occurring alternans.