Summary
International Symposium on Nonlinear Theory and Its Applications
2015
Session Number:A5L-C
Session:
Number:A5L-C-2
Bifurcation Analysis of Human Ventricular Myocyte Model and its Quantitative Evaluation Towards the Creation of Biological Pacemakers
Yoshiki Ogawa, Shinji Doi,
pp.373-376
Publication Date:2015/12/1
Online ISSN:2188-5079
DOI:10.34385/proc.47.A5L-C-2
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Summary:
In ventricular myocytes, pacemaker activity is induced by changing ionic currents across the cell membrane, although these cells are intrinsically quiescent non-pacemaking cells. These artificial pacemaker cells created from quiescent cardiomyocytes are called biological pacemaker, which is expected as an alternative to electronic pacemaker. Since it is necessary for biological pacemaker engineering (creation of biological pacemaker cells) to understand the dynamics of various ion channels comprehensively, we use the mathematical cell model. In this paper, we reveal that pacemaker activity is generated by changing inward rectifier potassium current and hyperpolarization-activated current based on the bifurcation analysis of a mathematical model of human ventricular myocytes.