Summary
International Symposium on Nonlinear Theory and Its Applications
2016
Session Number:A4L-F
Session:
Number:A4L-F-1
Abnormal Cardiac Conduction in Acquired Heart Disease: a Simulation Study
Kunichika Tsumoto, Yoshihisa Kurachi,
pp.-
Publication Date:2016/11/27
Online ISSN:2188-5079
Summary:
The voltage-gated sodium (Na) channels, playing key roles in the action potential (AP) initiation and the propagation, alters the distribution within a myocyte in congenital and acquired disorder. Here, we show that the Na channel distribution at the subcellular level may be partly contributed to the conduction disorder and the initiation of reentrant tachyarrhythmia by using computer simulation. These results suggest that the function of ion channels as well as the subcellular distribution may be partly responsible for the occurrence of lethal arrhythmia.