Summary

International Symposium on Nonlinear Theory and Its Applications

2015

Session Number:A2L-A

Session:

Number:A2L-A-4

Features of the Primate Connectome Revealed by Trade-Off Between Wiring Cost and Efficiency

Yuhan Chen,  Shengjun Wang,  Claus C Hilgetag,  Changsong Zhou,  

pp.14-17

Publication Date:2015/12/1

Online ISSN:2188-5079

DOI:10.34385/proc.47.A2L-A-4

PDF download (424.2KB)

Summary:
The anatomical primate connectome has some pronounced properties, highly related to the information processing and brain disorder disease. However, the mechanism underlying the network properties, especially the relationship between the spatial layout and anatomical connectome, is not clear. This work studied the influence of two important but competing constraints of wiring cost and efficiency on the Macaque anatomical wiring diagram. It is revealed that the existence of similar modular and multiple hubs structure, even the location of hubs is attributed to a proper trade-off between the two fundamental constraints. However, the degrees of non-hubs cannot be fully explained by the two constraints. Further fixing the degrees of cortical areas, nearly 70 % of connections of Macaque connectome can be recovered under the trade-off between the wiring cost and processing efficiency constraints. These findings suggest that the cost-efficiency trade-off contribute to the characteristic architecture of neural networks at different scales.