| Presentation | 2015-03-17 Mathematical model for collective cell migration regulated by external molecular signal Akio MURASE, NAOKI Honda, Shin ISHII, |
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| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | During the embryonic development, neural networks and organs are shaped by collective multicellular migration. Thus, it is important for elucidating the mechanism by which the cellular cohort collectively migrates. In this study, we focused on wound healing regulated by the collective cell migration, and then developed simple mathematical model for multicellular migration on epithetical sheet. We examined how is the collective cell migration regulated by traveling wave of motility-inducing molecular signal generated from wound region, which was recently discovered as spatial propagation of radial ERK activity distribution (SPREAD). By performing the simulation, we found that the traveling wave of the molecular signal could be the best strategy for facilitating collective cell migration for the wound healing. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Wound healing / Multi-cell migration / SPREAD / ERK / Cellular automaton / Random walk |
| Paper # | MBE2014-160,NC2014-111 |
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| Conference Information | |
| Committee | NC |
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| Conference Date | 2015/3/9(1days) |
| Place (in Japanese) | (See Japanese page) |
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| Topics (in Japanese) | (See Japanese page) |
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| Paper Information | |
| Registration To | Neurocomputing (NC) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Mathematical model for collective cell migration regulated by external molecular signal |
| Sub Title (in English) | |
| Keyword(1) | Wound healing |
| Keyword(2) | Multi-cell migration |
| Keyword(3) | SPREAD |
| Keyword(4) | ERK |
| Keyword(5) | Cellular automaton |
| Keyword(6) | Random walk |
| 1st Author's Name | Akio MURASE |
| 1st Author's Affiliation | Graduate school of informatics, Kyoto University() |
| 2nd Author's Name | NAOKI Honda |
| 2nd Author's Affiliation | Graduate school of medicine, Kyoto University |
| 3rd Author's Name | Shin ISHII |
| 3rd Author's Affiliation | Graduate school of informatics, Kyoto University |
| Date | 2015-03-17 |
| Paper # | MBE2014-160,NC2014-111 |
| Volume (vol) | vol.114 |
| Number (no) | 515 |
| Page | pp.pp.- |
| #Pages | 4 |
| Date of Issue | |