| Presentation | 2015-03-16 Voltage imaging of the neural excitation area in response to intra-cortical microstimulation Yuta TANAKA, Yuki HAYASHIDA, Yuya SAKATA, Tetsuya YAGI, |
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| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | In physiological experiments using neural tissues, extra-cellular current stimulation delivered through the electrode inserted in the tissue has been widely used to elucidate functional structures of the target neural circuit. However, it is still controversial on the spatial extent of neural excitation in response to even single electrode stimulation, since previous studies on this respect have been based on electrophysiological measurements. Therefore in this study, we measured the spatial area of supra-threshold neural excitation induced by single pulse current stimuli in mouse cerebral slices, by utilizing high-speed voltage sensitive dye imaging technique. The experimental results suggested that, under blockading excitatory synaptic transmissions, action potential firings are initiated within 2 msec post-stimulus around the stimulating electrode, and propagated to its periphery through the axons and dendrites afterwards. And the spatial extent where the action potentials are initiated is increased as the stimulus current amplitude is larger. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Extra-cellular current stimulation / Stimulus area / Voltage imaging / Mouse |
| Paper # | MBE2014-118,NC2014-69 |
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| Conference Information | |
| Committee | NC |
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| Conference Date | 2015/3/9(1days) |
| Place (in Japanese) | (See Japanese page) |
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| Topics (in Japanese) | (See Japanese page) |
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| Registration To | Neurocomputing (NC) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Voltage imaging of the neural excitation area in response to intra-cortical microstimulation |
| Sub Title (in English) | |
| Keyword(1) | Extra-cellular current stimulation |
| Keyword(2) | Stimulus area |
| Keyword(3) | Voltage imaging |
| Keyword(4) | Mouse |
| 1st Author's Name | Yuta TANAKA |
| 1st Author's Affiliation | Graduate School of Engineering, Osaka Univ.() |
| 2nd Author's Name | Yuki HAYASHIDA |
| 2nd Author's Affiliation | Graduate School of Engineering, Osaka Univ. |
| 3rd Author's Name | Yuya SAKATA |
| 3rd Author's Affiliation | Graduate School of Engineering, Osaka Univ. |
| 4th Author's Name | Tetsuya YAGI |
| 4th Author's Affiliation | Graduate School of Engineering, Osaka Univ. |
| Date | 2015-03-16 |
| Paper # | MBE2014-118,NC2014-69 |
| Volume (vol) | vol.114 |
| Number (no) | 515 |
| Page | pp.pp.- |
| #Pages | 6 |
| Date of Issue | |