Presentation 2014-12-13
Simulation analysis of endothelial function and pulse wave velocity
Yohei KONDO, Yoichi YAMAZAKI, Yoshimi KAMIYAMA,
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Abstract(in English) It is known that the early sign of atherosclerosis is a reduction of endothelial function. The assessment of FMD (Flow Mediated Dilation) has been widely used as a noninvasive method to evaluate the endothelial function. FMD is induced in response to changes in the mechanical structure of the vessel wall due to the blood flow stimulation. The changes in the mechanical structure of the vessel wall are supposed to affect the hemodynamics. In order to analyze the relationship between the mechanical structure and hemodynamics, simultaneous analysis of the hemodynamics and vasomotion is required. In this study, we proposed an integrated model of hemodynamics and vasomototion, and we simulated the FMD response. We also analyzed the relationship between PWV (Pulse Wave Velocity) and FMD response.
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Keyword(in English) arteriosclerosis / endothelial function / pulse wave velocity / computational model / simulation
Paper # MBE2014-89
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Committee MBE
Conference Date 2014/12/6(1days)
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Registration To ME and Bio Cybernetics (MBE)
Language JPN
Title (in Japanese) (See Japanese page)
Sub Title (in Japanese) (See Japanese page)
Title (in English) Simulation analysis of endothelial function and pulse wave velocity
Sub Title (in English)
Keyword(1) arteriosclerosis
Keyword(2) endothelial function
Keyword(3) pulse wave velocity
Keyword(4) computational model
Keyword(5) simulation
1st Author's Name Yohei KONDO
1st Author's Affiliation Information Science and Technology, Aichi Prefectural University()
2nd Author's Name Yoichi YAMAZAKI
2nd Author's Affiliation Information Science and Technology, Aichi Prefectural University:Priority Research Project, Aichi Science and Technology Foundation
3rd Author's Name Yoshimi KAMIYAMA
3rd Author's Affiliation Information Science and Technology, Aichi Prefectural University
Date 2014-12-13
Paper # MBE2014-89
Volume (vol) vol.114
Number (no) 361
Page pp.pp.-
#Pages 6
Date of Issue