| Presentation | 2014-05-26 Development and consideration on applicability of culture flask for brain tumor cells with acoustic window film for ultrasound exposure Sakino Iwashiro, Akiko Watanabe, Yoshifumi Onozuka, Masatsune Minai, Hiroyuki Nishimura, Shinichi Takeuchi, |
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| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | In recent years, the transscanial brain tumor treatment system by High Intensity Focused Ultrasound (HIFU) has been studied. This treatment has the advantage that it is minimally invasive and it can be applied repeatedly unlike radiotherapy. However, when brain tumor cells are coagulated and are necrotized with this treatment system, the surrounding normal brain tissue may be affected by the necrosis. Therefore, we have been developing the treatment method of brain tumor cells without necrosis by ultrasound exposure. When the commercial polystyrene cell culture flasks with thickness of about 2mm were employed as containers of target brain tumor cells exposed to ultrasound, there was a problem that ultrasound energy was reflected at the surface of the flask with different specific acoustic impedance from water outside of the flask and culture medium in the flask, but did not reach the cells sufficiently. Therefore, it is difficult to estimate the ultrasound energy reached to the cells on the inside surface of bottom polystyrene plate of the commercial cell culture flask. In addition, it is necessary to position the bottom of the flask in the ultrasound wave beam completely. Therefore, we prepared the original cell culture flasks with acoustic window for ultrasound exposure and cell culture. This report describes the study on development of cell culture flask with a thin polymer film acoustic window for culture of adherent cell and ultrasound irradiation. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | adherent cell / cell culture flask / acoustic window film / brain tumor cell |
| Paper # | US2014-13 |
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| Conference Information | |
| Committee | US |
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| Conference Date | 2014/5/19(1days) |
| Place (in Japanese) | (See Japanese page) |
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| Topics (in Japanese) | (See Japanese page) |
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| Registration To | Ultrasonics (US) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Development and consideration on applicability of culture flask for brain tumor cells with acoustic window film for ultrasound exposure |
| Sub Title (in English) | |
| Keyword(1) | adherent cell |
| Keyword(2) | cell culture flask |
| Keyword(3) | acoustic window film |
| Keyword(4) | brain tumor cell |
| 1st Author's Name | Sakino Iwashiro |
| 1st Author's Affiliation | Graduate school of Engineering, Toin University of Yokohama() |
| 2nd Author's Name | Akiko Watanabe |
| 2nd Author's Affiliation | Graduate school of Engineering, Toin University of Yokohama:Fukuoka University |
| 3rd Author's Name | Yoshifumi Onozuka |
| 3rd Author's Affiliation | Seidensha Electronics CO., LTD. |
| 4th Author's Name | Masatsune Minai |
| 4th Author's Affiliation | Graduate school of Engineering, Toin University of Yokohama |
| 5th Author's Name | Hiroyuki Nishimura |
| 5th Author's Affiliation | Graduate school of Engineering, Toin University of Yokohama |
| 6th Author's Name | Shinichi Takeuchi |
| 6th Author's Affiliation | Graduate school of Engineering, Toin University of Yokohama |
| Date | 2014-05-26 |
| Paper # | US2014-13 |
| Volume (vol) | vol.114 |
| Number (no) | 54 |
| Page | pp.pp.- |
| #Pages | 6 |
| Date of Issue | |