Presentation 2013-11-27
An Optimal Sample Preparation Algorithm for Digital Microfluidic Biochips
Trung ANH DINH, Shigeru YAMASHITA, Tsung-Yi HO,
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Abstract(in English) Sample preparation, which is a front-end process to produce droplets of the desired target concentrations from input reagents, plays a pivotal role in every assay, laboratory, and application in biomedical engineering and life science. The consumption of expensive sample is usually used to evaluate the effectiveness of a sample preparation process. In this paper, we present the first optimal sample preparation algorithm based on a minimum-cost maximum-flow model. By using the proposed model, we can obtain the optimal cost of sample usage even for multiple-target concentrations. Experiments demonstrate that we can consistently achieve much better results not only in the consumption of sample usage but also the consumption of buffer usage as well as the waste amount when compared with the state-of-the-art of the previous approaches.
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Keyword(in English) digital microfluidic biochips / sample preparation / minimum-cost maximum flow / integer equal flows
Paper # VLD2013-64,DC2013-30
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Committee DC
Conference Date 2013/11/20(1days)
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Language ENG
Title (in Japanese) (See Japanese page)
Sub Title (in Japanese) (See Japanese page)
Title (in English) An Optimal Sample Preparation Algorithm for Digital Microfluidic Biochips
Sub Title (in English)
Keyword(1) digital microfluidic biochips
Keyword(2) sample preparation
Keyword(3) minimum-cost maximum flow
Keyword(4) integer equal flows
1st Author's Name Trung ANH DINH
1st Author's Affiliation Ritsumeikan University()
2nd Author's Name Shigeru YAMASHITA
2nd Author's Affiliation Ritsumeikan University
3rd Author's Name Tsung-Yi HO
3rd Author's Affiliation National Cheng Kung University
Date 2013-11-27
Paper # VLD2013-64,DC2013-30
Volume (vol) vol.113
Number (no) 321
Page pp.pp.-
#Pages 6
Date of Issue