| Presentation | 2013-05-24 Ghrelin depolarizes hypothalamic tuberomammillary nucleus neuroi Yuji WAKABAYASHI, Juhyon KIM, Kazuki NAKAJIMA, |
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| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | Ghrelin, known as stimulator of release of growth hormone (GH) and food intake, is produced by stomach, other peripheral organs and some brain regions and acts on GH secretagogue receptor (GHS-R) in the some peripheral organs and brain regions. It suggests that ghrelin participates in not only regulation of GH release, feeding but several functions. Recent study demonstrated that ghrelin also participates regulation of sleep-wakefulness. Tuberomammillary nucleus (TMN), which is one of brain sites that control sleep-wakefulness, also expresses GHS-R. However, the action of ghrelin on TMN neurons is remained unclear. Thus, we examined effects of ghrelin on TMN neurons using rat brain slice preparations and whole-cell patch clamp recording technique. Application of ghrelin depolarized TMN neurons dose-dependently and ghrelin-induced depolarization was also observed under presence of tetrodotoxin. These results suggest that ghrelin depolarizes TMN neurons and participates in the regulation of sleep-wakefulness via the excitatory effect on TMN neurons. |
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| Paper # | MBE2013-3 |
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| Committee | MBE |
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| Conference Date | 2013/5/17(1days) |
| Place (in Japanese) | (See Japanese page) |
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| Registration To | ME and Bio Cybernetics (MBE) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Ghrelin depolarizes hypothalamic tuberomammillary nucleus neuroi |
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| 1st Author's Name | Yuji WAKABAYASHI |
| 1st Author's Affiliation | Faculty of Engineering, University of Toyama() |
| 2nd Author's Name | Juhyon KIM |
| 2nd Author's Affiliation | Faculty of Engineering, University of Toyama |
| 3rd Author's Name | Kazuki NAKAJIMA |
| 3rd Author's Affiliation | Faculty of Engineering, University of Toyama |
| Date | 2013-05-24 |
| Paper # | MBE2013-3 |
| Volume (vol) | vol.113 |
| Number (no) | 61 |
| Page | pp.pp.- |
| #Pages | 3 |
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