| Presentation | 2013-01-24 Measurement of the specific adsorption of biotinylated microbubbles using a quartz crystal microbalance Takashige MURAMOTO, Ryosuke SHIMOYA, Kenji YOSHIDA, Yoshiaki WATANABE, |
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| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | In addition to the application of microbubbles as contrast agent for diagnostic ultrasound, microbubbles are also applied as the drug camer in drug delivery system. Targeting microbubbles enables to get the strong signal on ultrasound tissue imaging and deliver drug to the objective site. In this report, we prepared biotinylated mirobubbles and evaluated the specific adsorption of microbubbles with a quartz crystal sensor. When a substance deposited on the QCM electrode, the resonance frequency decreases. By tracking resonance frequency, we can observe attachment of microbubbles. We attached Biotin-SAMs on the QCM electrode and monitored binding behavior of streptavidm and biotinylated microbubles. The resonance frequency declined rapidly by biotinylated microbubbles compared to the case of normal microbubbles. That indicates this method is effective to evaluate the specific adsorption of microbubbles |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Ultrasound / Microbubble / Specific adsorption / Piezoelectric sensor / Drug Delivery System |
| Paper # | US2012-88 |
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| Conference Information | |
| Committee | US |
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| Conference Date | 2013/1/17(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
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| Paper Information | |
| Registration To | Ultrasonics (US) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Measurement of the specific adsorption of biotinylated microbubbles using a quartz crystal microbalance |
| Sub Title (in English) | |
| Keyword(1) | Ultrasound |
| Keyword(2) | Microbubble |
| Keyword(3) | Specific adsorption |
| Keyword(4) | Piezoelectric sensor |
| Keyword(5) | Drug Delivery System |
| 1st Author's Name | Takashige MURAMOTO |
| 1st Author's Affiliation | Faculty of Life and Medical Sciences,Doshlsha University() |
| 2nd Author's Name | Ryosuke SHIMOYA |
| 2nd Author's Affiliation | Faculty of Engeneering,Doshlsha University |
| 3rd Author's Name | Kenji YOSHIDA |
| 3rd Author's Affiliation | Faculty of Life and Medical Sciences,Doshlsha University |
| 4th Author's Name | Yoshiaki WATANABE |
| 4th Author's Affiliation | Faculty of Life and Medical Sciences,Doshlsha University |
| Date | 2013-01-24 |
| Paper # | US2012-88 |
| Volume (vol) | vol.112 |
| Number (no) | 387 |
| Page | pp.pp.- |
| #Pages | 6 |
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