| Presentation | 2012-07-31 Subthalamic nucleus neuron model displaying a dopamine-depedent change in neural responses Hironori SAKURAI, Katsunori KITANO, |
|---|---|
| PDF Download Page |  PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | In the subthalamic nucleus (STN) neuron, it has been reported that dopamine depletion influences activation of some ion channels. In this study, we constructed the STN neuron model exhibiting dopamine-dependent responses in order to investigate relationship between the neuron's dopamine-dependent behavior and Parkinson's Disease. Our result suggested that HCN channels deficiency induced strong rebound burst firings and down-regulation of Cav2.2 channels prevented Na^+ channels from being sufficiently recovered. This meant that available Na^+ channels were decreased and caused reduction of the velocity during action potential generation. Therefore, under the dopamine depleted condition, the STN neuron model is likely to be more strongly affected by background noise, and consequently to exhibit an irregular spontaneous activity. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Subthalamic nucleus neuron / Parkinson's disease / HCN channels Cav2.2 channels / Navl.6 sodium channels |
| Paper # | NC2012-20 |
| Date of Issue |
| Conference Information | |
| Committee | NC |
|---|---|
| Conference Date | 2012/7/23(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | |
| Chair | |
| Vice Chair | |
| Secretary | |
| Assistant | |
| Paper Information | |
| Registration To | Neurocomputing (NC) |
|---|---|
| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Subthalamic nucleus neuron model displaying a dopamine-depedent change in neural responses |
| Sub Title (in English) | |
| Keyword(1) | Subthalamic nucleus neuron |
| Keyword(2) | Parkinson's disease |
| Keyword(3) | HCN channels Cav2.2 channels |
| Keyword(4) | Navl.6 sodium channels |
| 1st Author's Name | Hironori SAKURAI |
| 1st Author's Affiliation | Graduate school of Science and Engineering, Ritsumeikan University() |
| 2nd Author's Name | Katsunori KITANO |
| 2nd Author's Affiliation | Department of Human and Computer Intelligence, Ritsumeikan University |
| Date | 2012-07-31 |
| Paper # | NC2012-20 |
| Volume (vol) | vol.112 |
| Number (no) | 168 |
| Page | pp.pp.- |
| #Pages | 5 |
| Date of Issue | |