| Presentation | 2012/6/21 Structure prediction with FAMS for proteins screened critically to autoimmune diseases based upon bioimformatics SHIGEHARU ISHIDA, HIDEAKI UMEYAMA, MITSUO IWADATE, Y-H. TAGUCHI, |
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| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | Drug discovery for autoimmune diseases is recently recognized to be an important task. In this study, we try to perform structure prediction of proteins whose gene promoter regions were previous reported to be specifically methelysed or de-methylased commonly for three autoimmune diseases, systemic lupus erythematosus, rheumatoid arthritis, and dermatomyositis. FAMS were employed for this purpose and we can predict three dimensional structure with significantly small enough P-values. Most of them are suggested to be self immunology related proteins and will be important drug target candidates. We also found some proteins which form complex with each other. The possibility of a new drug target, i.e., suppression of protein complex formation is suggested. |
| Keyword(in Japanese) | (See Japanese page) |
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| Paper # | Vol.2012-BIO-29 No.12 |
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| Conference Information | |
| Committee | NC |
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| Conference Date | 2012/6/21(1days) |
| Place (in Japanese) | (See Japanese page) |
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| Topics (in Japanese) | (See Japanese page) |
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| Registration To | Neurocomputing (NC) |
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| Language | ENG |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Structure prediction with FAMS for proteins screened critically to autoimmune diseases based upon bioimformatics |
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| 1st Author's Name | SHIGEHARU ISHIDA |
| 1st Author's Affiliation | Department of Physics, Chuo University() |
| 2nd Author's Name | HIDEAKI UMEYAMA |
| 2nd Author's Affiliation | Department of Biological Sciences, Chuo University |
| 3rd Author's Name | MITSUO IWADATE |
| 3rd Author's Affiliation | Department of Biological Sciences, Chuo University |
| 4th Author's Name | Y-H. TAGUCHI |
| 4th Author's Affiliation | Department of Physics, Chuo University |
| Date | 2012/6/21 |
| Paper # | Vol.2012-BIO-29 No.12 |
| Volume (vol) | vol.112 |
| Number (no) | 108 |
| Page | pp.pp.- |
| #Pages | 6 |
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