| Presentation | 2012-06-28 An Estimation of Cell Forces with Hierarchical Bayes Approach Considering Cell Morphology Satoshi KOZAWA, Yuichi SAKUMURA, Michinori TORIYAMA, Naoyuki INAGAKI, Kazushi IKEDA, |
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| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | To elucidate the migration mechanism of a biological cell, a mechanical force generated by the cell is measured in many biological studies. One of popular techniques is to measure the locations of fluorescent nano beads which are embedded in the surface of the culture substrate. A force is estimated from bead transitions. However, it is difficult inverse problem to estimate forces from the transitions because the number of possible force points is much larger than that of embedded beads due to physical limitations. To solve this problem, in this study we propose Bayesian force estimation by introducing priors of the cell morphology and the force directions, with the EM algorithm for parameter estimation. Our algorithm shows a significant improvement in estimating a force. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Traction force microscopy (TFM) / cell / inverse problem / Bayesian estimation |
| Paper # | NC2012-8 |
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| Committee | NC |
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| Conference Date | 2012/6/21(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
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| Paper Information | |
| Registration To | Neurocomputing (NC) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | An Estimation of Cell Forces with Hierarchical Bayes Approach Considering Cell Morphology |
| Sub Title (in English) | |
| Keyword(1) | Traction force microscopy (TFM) |
| Keyword(2) | cell |
| Keyword(3) | inverse problem |
| Keyword(4) | Bayesian estimation |
| 1st Author's Name | Satoshi KOZAWA |
| 1st Author's Affiliation | Graduate School of Information Science, Nara Institute of Science and Technology() |
| 2nd Author's Name | Yuichi SAKUMURA |
| 2nd Author's Affiliation | School of Information Science and Technology, Aichi Prefectural University |
| 3rd Author's Name | Michinori TORIYAMA |
| 3rd Author's Affiliation | Graduate School of Biological Science, Nara Institute of Science and Technology |
| 4th Author's Name | Naoyuki INAGAKI |
| 4th Author's Affiliation | Graduate School of Biological Science, Nara Institute of Science and Technology |
| 5th Author's Name | Kazushi IKEDA |
| 5th Author's Affiliation | Graduate School of Information Science, Nara Institute of Science and Technology |
| Date | 2012-06-28 |
| Paper # | NC2012-8 |
| Volume (vol) | vol.112 |
| Number (no) | 108 |
| Page | pp.pp.- |
| #Pages | 4 |
| Date of Issue | |