| Presentation | 2012-01-20 Development of automated method for extraction of hippocampal regions for computer-aided diagnosis of dementia of Alzheimer type Sho Araki, Hidetaka Arimura, Takashi Yoshiura, Chiaki Tokunaga, Yasuo Yamashita, Hiroshi Honda, Hideki Hirata, Fukai Toyofuku, Masafumi Ohki, |
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| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | Although image features of hippocampal regions including their volumes and shapes would be feasible for diagnosing the dementia of Alzheimer type (DAT) in early stages, it would be very difficult to quantify such features and would be time-consuming to diagnose the DAT. We have attempted to develop an automated segmentation method for three-dimensional (3D) hippocampal regions in magnetic resonance (MR) images. First, hippocampal probabilistic atlases were produced by registering all images of 9 control subjects, which include hippocampal regions determined by a manual method, to a reference image of a subject by using a linear registration followed by a non-linear registration. Next, pixel value probability distributions of the hippocampal regions and their surroundings were obtained from the corresponding regions in all training cases. Finally, hippocampal region of each case was estimated based on a maximum a posteriori estimation using the probabilistic atlas and the pixel value probability distributions of the hippocampal regions and their surroundings. For evaluation of the proposed method, we applied it to ten training cases, and then calculated a Dice similarity coefficient (DSC), which was the degree of the agreement between the hippocampal regions determined by the manual method and the proposed method. The average DSC was 0.63±0.13. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Dementia of Alzheimer type / Magnetic resonance (MR) image / Computer aided diagnosis system / Hippocampus / Maximum a posteriori estimation |
| Paper # | MI2011-120 |
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| Conference Information | |
| Committee | MI |
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| Conference Date | 2012/1/12(1days) |
| Place (in Japanese) | (See Japanese page) |
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| Topics (in Japanese) | (See Japanese page) |
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| Registration To | Medical Imaging (MI) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Development of automated method for extraction of hippocampal regions for computer-aided diagnosis of dementia of Alzheimer type |
| Sub Title (in English) | |
| Keyword(1) | Dementia of Alzheimer type |
| Keyword(2) | Magnetic resonance (MR) image |
| Keyword(3) | Computer aided diagnosis system |
| Keyword(4) | Hippocampus |
| Keyword(5) | Maximum a posteriori estimation |
| 1st Author's Name | Sho Araki |
| 1st Author's Affiliation | Graduate School of Medical Sciences, Kyushu University() |
| 2nd Author's Name | Hidetaka Arimura |
| 2nd Author's Affiliation | Faculty of Medical Sciences, Kyushu University |
| 3rd Author's Name | Takashi Yoshiura |
| 3rd Author's Affiliation | Faculty of Medical Sciences, Kyushu University |
| 4th Author's Name | Chiaki Tokunaga |
| 4th Author's Affiliation | Graduate School of Medical Sciences, Kyushu University |
| 5th Author's Name | Yasuo Yamashita |
| 5th Author's Affiliation | Graduate School of Medical Sciences, Kyushu University |
| 6th Author's Name | Hiroshi Honda |
| 6th Author's Affiliation | Faculty of Medical Sciences, Kyushu University |
| 7th Author's Name | Hideki Hirata |
| 7th Author's Affiliation | Faculty of Medical Sciences, Kyushu University |
| 8th Author's Name | Fukai Toyofuku |
| 8th Author's Affiliation | Faculty of Medical Sciences, Kyushu University |
| 9th Author's Name | Masafumi Ohki |
| 9th Author's Affiliation | Faculty of Medical Sciences, Kyushu University |
| Date | 2012-01-20 |
| Paper # | MI2011-120 |
| Volume (vol) | vol.111 |
| Number (no) | 389 |
| Page | pp.pp.- |
| #Pages | 4 |
| Date of Issue | |