| Presentation | 2012-01-19 Bayesian Approach for the Denoising to PET Dyanamic Data without Arterial Blood Sampling Takahiro KOZAWA, Hidekata HONTANI, Kazuya SAKAGUCHI, Muneyuki SAKATA, Yuichi KIMURA, |
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| PDF Download Page |  PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | In this report, we propose a new method for denoising tissue time activity curve (tTAC) measured from brain PET images. tTAC is a curve representing time variation of radioactivity of ligand in the brain and used receptor analysis in combination with the plasma time activity curve (pTAC), which is obtained by drawing arterial blood. Large amount of noise in measured tTAC reduces accuracy of the estimation, so the accuracy of the estimation is improved by denoising tTAC. It is known that noise free tTAC is represented by the observed pTAC and the compartment model, which is derived from the behavior of ligand. The authors have proposed a method for denoising tTAC by using the measured pTAC and the compartment model. The drawback of the method was that it used the pTAC, which is not easy to measure. The proposed method expands the method: it denoises tTACs without using measured pTAC. In this article, we shows some results of fundamental experiments. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | PET / denoising / kinetic analysis / total distribution volume / Bayes estimation |
| Paper # | MI2011-79 |
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| Conference Information | |
| Committee | MI |
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| Conference Date | 2012/1/12(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
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| Paper Information | |
| Registration To | Medical Imaging (MI) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Bayesian Approach for the Denoising to PET Dyanamic Data without Arterial Blood Sampling |
| Sub Title (in English) | |
| Keyword(1) | PET |
| Keyword(2) | denoising |
| Keyword(3) | kinetic analysis |
| Keyword(4) | total distribution volume |
| Keyword(5) | Bayes estimation |
| 1st Author's Name | Takahiro KOZAWA |
| 1st Author's Affiliation | Nagoya Institute of Technology() |
| 2nd Author's Name | Hidekata HONTANI |
| 2nd Author's Affiliation | Nagoya Institute of Technology |
| 3rd Author's Name | Kazuya SAKAGUCHI |
| 3rd Author's Affiliation | Kitasato University |
| 4th Author's Name | Muneyuki SAKATA |
| 4th Author's Affiliation | Positron Medical Center |
| 5th Author's Name | Yuichi KIMURA |
| 5th Author's Affiliation | Molecular Imaging Center |
| Date | 2012-01-19 |
| Paper # | MI2011-79 |
| Volume (vol) | vol.111 |
| Number (no) | 389 |
| Page | pp.pp.- |
| #Pages | 6 |
| Date of Issue | |