| Presentation | 2012-01-28 Synchronized Bursting between Primary and Pluripotent Cell-derived Neurons Kenta SHIMBA, Atsushi SAITO, Yuzo TAKAYAMA, Kiyoshi KOTANI, Yasuhiko JIMBO, |
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| PDF Download Page |  PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | In order to study whether stem cell-derived neurons were integrated into primary neuronal network, a co-culture device was developed, which can be utilized to compartmentalize primary cortical neurons and stem cell-derived neurons and record their spontaneous activities. After six days in co-culture, synchronized bursting between both neuronal networks was observed. Moreover, more than half of synchronized activities were generated by primary cortical neurons, and stem cell-derived neurons fired within 250 ms of bursting activity of cortical neurons. These results suggest that this co-culture device is useful for evaluating the interaction between primary and stem cell-derived neuronal networks. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | microelectrode array / neuronal network / stem cell / co-culture / tissue engineering / micro fabrication technique |
| Paper # | MBE2011-104 |
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| Conference Information | |
| Committee | MBE |
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| Conference Date | 2012/1/20(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | |
| Chair | |
| Vice Chair | |
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| Paper Information | |
| Registration To | ME and Bio Cybernetics (MBE) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Synchronized Bursting between Primary and Pluripotent Cell-derived Neurons |
| Sub Title (in English) | |
| Keyword(1) | microelectrode array |
| Keyword(2) | neuronal network |
| Keyword(3) | stem cell |
| Keyword(4) | co-culture |
| Keyword(5) | tissue engineering |
| Keyword(6) | micro fabrication technique |
| 1st Author's Name | Kenta SHIMBA |
| 1st Author's Affiliation | Graduate School of Frontier Sciences. University of Tokvo() |
| 2nd Author's Name | Atsushi SAITO |
| 2nd Author's Affiliation | Graduate School of Frontier Sciences. University of Tokvo |
| 3rd Author's Name | Yuzo TAKAYAMA |
| 3rd Author's Affiliation | Graduate School of Information Science and Technology, University of Tokyo |
| 4th Author's Name | Kiyoshi KOTANI |
| 4th Author's Affiliation | Graduate School of Frontier Sciences. University of Tokvo |
| 5th Author's Name | Yasuhiko JIMBO |
| 5th Author's Affiliation | Graduate School of Frontier Sciences. University of Tokvo |
| Date | 2012-01-28 |
| Paper # | MBE2011-104 |
| Volume (vol) | vol.111 |
| Number (no) | 423 |
| Page | pp.pp.- |
| #Pages | 4 |
| Date of Issue | |