| Presentation | 2011-11-24 Numerical simulation of response of nerve fibers to electrical stimulation with staircase waveforms Ayako UENO, Norihiro KATAYAMA, Akihiro KARASHIMA, Mitsuyuki NAKAO, |
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| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | It has been suggested that the electrode-to-axonal distance selective recruitment of relatively thick myelinated axons can be achieved by the down staircase-shape electrical nerve stimulation delivered from an extracellular electrode. However, the response of thin axons such as stimulus pulse duration dependency has not clarified. In this research, we investigated the pulse duration-dependency of the response of a thin myelinated axon model to square pulse stimulation by the numerical simulation. It was shown that short pulse stimulus (duration = 50 μs) activated only axons close to the electrode. In contrast, the stimulus with longer duration (e.g. 200 μs) activated more distant axons without activating near axons. However, stimulus with much longer duration (e.g. 500 μs) did not show distance-selective recruitment of axons due to occurrence of anodal break excitation of axons in the neighborhood of the electrode. In addition, thin axons (⪇1 μm) at more than 300 μm far from the electrode could not be activated by the square pulse stimulation. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | electrical stimulation / selective nerve stimulation / staircase-shape waveform / myelinated axon |
| Paper # | MBE2011-57 |
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| Conference Information | |
| Committee | MBE |
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| Conference Date | 2011/11/17(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
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| Paper Information | |
| Registration To | ME and Bio Cybernetics (MBE) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Numerical simulation of response of nerve fibers to electrical stimulation with staircase waveforms |
| Sub Title (in English) | |
| Keyword(1) | electrical stimulation |
| Keyword(2) | selective nerve stimulation |
| Keyword(3) | staircase-shape waveform |
| Keyword(4) | myelinated axon |
| 1st Author's Name | Ayako UENO |
| 1st Author's Affiliation | Graduate school of Information Sciences, Tohoku University() |
| 2nd Author's Name | Norihiro KATAYAMA |
| 2nd Author's Affiliation | Graduate school of Information Sciences, Tohoku University |
| 3rd Author's Name | Akihiro KARASHIMA |
| 3rd Author's Affiliation | Graduate school of Information Sciences, Tohoku University |
| 4th Author's Name | Mitsuyuki NAKAO |
| 4th Author's Affiliation | Graduate school of Information Sciences, Tohoku University |
| Date | 2011-11-24 |
| Paper # | MBE2011-57 |
| Volume (vol) | vol.111 |
| Number (no) | 314 |
| Page | pp.pp.- |
| #Pages | 6 |
| Date of Issue | |