| Presentation | 2011-07-26 Statistical estimation of non-uniform dendritic membrane properties Toshiaki OMORI, Toru AONISHI, Masato OKADA, |
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| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | We propose a statistical algorithm for extracting non-uniform dendritic membrane properties from partially observable noisy data such as voltage imaging data. Recent experimental studies suggest that dendritic computation plays an important role in information processing in local neural circuits. The non-uniform distribution of membrane properties over dendrite remains unclear, even though it determines how different kinds of information are integrated in neural systems. We formulate a state-space model for a multi-compartment model and derive a distributed-constant type Kalman filter by means of belief propagation. By using the derived Kalman filter and the EM algorithm, we show that our proposed algorithm can simultaneously estimate the spatiotemporal distribution of membrane potentials and the non-uniform distribution of membrane properties from partially observable noisy data. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | statistical estimation / state-space modeling / spatiotemporal dynamics / dendrite / imaging data / cable equation / probabilistic time series analysis |
| Paper # | NC2011-32 |
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| Conference Information | |
| Committee | NC |
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| Conference Date | 2011/7/18(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
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| Registration To | Neurocomputing (NC) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Statistical estimation of non-uniform dendritic membrane properties |
| Sub Title (in English) | |
| Keyword(1) | statistical estimation |
| Keyword(2) | state-space modeling |
| Keyword(3) | spatiotemporal dynamics |
| Keyword(4) | dendrite |
| Keyword(5) | imaging data |
| Keyword(6) | cable equation |
| Keyword(7) | probabilistic time series analysis |
| 1st Author's Name | Toshiaki OMORI |
| 1st Author's Affiliation | Graduate School of Frontier Sciences, The University of Tokyo:RIKEN Brain Science Institute() |
| 2nd Author's Name | Toru AONISHI |
| 2nd Author's Affiliation | Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology |
| 3rd Author's Name | Masato OKADA |
| 3rd Author's Affiliation | Graduate School of Frontier Sciences, The University of Tokyo:RIKEN Brain Science Institute |
| Date | 2011-07-26 |
| Paper # | NC2011-32 |
| Volume (vol) | vol.111 |
| Number (no) | 157 |
| Page | pp.pp.- |
| #Pages | 6 |
| Date of Issue | |