Presentation 2011-05-20
An attempt of Urine Hippuric Acid Detection Using Near-infrared Spectroscopy : Towards to Biological Exposure Indices Measurement
Koji NISHIDA, Mitsuhiro OGAWA, Atsuo SAITO, Yuting FAN, Kosuke MOTOI, Takehiro YAMAKOSHI, Kenichi YAMAKOSHI,
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Abstract(in English) Biological Exposure Indices (BEIs) are reference for a chemical or its final metabolite in the biological specimen. BEIs can give guidelines for diagnosis of occupational illnesses and for the evaluation of potential health hazards. Among them, urine hippuric acid (HA), the final metabolites of toluene is considered as the BEIs of toluene exposure for workers using toluene. In this study, we attempted to develop a brief measurement of HA solution by using near-infrared spectroscopy. As the first step, artificial urines conditioned by adding urea to HA solutions were measured and analyzed. The solvents are optically measured within near infrared region (750-2500nm) obtaining optical absorption for obtaining differential absorbance from pure water. As a result, spectral peaks derived from HA clearly obtained even with urea. This result suggests that a brief urine constituents measurement using near-infrared spectroscopy can be developed.
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Keyword(in English) Hippuric Acid / Urea / Near Infrared / Absorbance / Biological Exposure Indices
Paper # MBE2011-3
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Conference Information
Committee MBE
Conference Date 2011/5/13(1days)
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Registration To ME and Bio Cybernetics (MBE)
Language JPN
Title (in Japanese) (See Japanese page)
Sub Title (in Japanese) (See Japanese page)
Title (in English) An attempt of Urine Hippuric Acid Detection Using Near-infrared Spectroscopy : Towards to Biological Exposure Indices Measurement
Sub Title (in English)
Keyword(1) Hippuric Acid
Keyword(2) Urea
Keyword(3) Near Infrared
Keyword(4) Absorbance
Keyword(5) Biological Exposure Indices
1st Author's Name Koji NISHIDA
1st Author's Affiliation Graduate School of Natural Science & Technology, Kanazawa University()
2nd Author's Name Mitsuhiro OGAWA
2nd Author's Affiliation Graduate School of Science & Engineering, Kanazawa University
3rd Author's Name Atsuo SAITO
3rd Author's Affiliation Graduate School of Natural Science & Technology, Kanazawa University
4th Author's Name Yuting FAN
4th Author's Affiliation Graduate School of Natural Science & Technology, Kanazawa University
5th Author's Name Kosuke MOTOI
5th Author's Affiliation Graduate School of Science & Engineering, Kanazawa University
6th Author's Name Takehiro YAMAKOSHI
6th Author's Affiliation Graduate School of Natural Science & Technology, Kanazawa University
7th Author's Name Kenichi YAMAKOSHI
7th Author's Affiliation Graduate School of Science & Engineering, Kanazawa University
Date 2011-05-20
Paper # MBE2011-3
Volume (vol) vol.111
Number (no) 57
Page pp.pp.-
#Pages 5
Date of Issue