| Presentation | 2011-01-27 Slow-inactivation of voltage-gated Na^+ current and spike firing in rat retinal neurons Sho HARABE, Tamami MOTOMURA, Yuki HAYASHIDA, Nobuki MURAYAMA, |
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| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | Ganglion cells located at the output of vertebrate retina encode the computational results of the neural circuit into electrical spike trains, to send the information to the brain. Recent studies have shown that voltage-gated Na^+ channels, which are responsible for the spike generation, exhibit inactivation with the time constants in the range between a few milliseconds and several hundred milliseconds, thereby contributing to the adaptive output of spikes. However, the slower inactivation in the time scale over seconds has not been previously analyzed in the physiological experiment. In this study, therefore, we made analyses on the transition process of the slow-inactivation of voltage-gated Na^+ current in the ganglion cells acutely dissociated from rat retinas, by means of voltage-clamp experiments with perforated-patch whole-cell mode. The results indicated that there exist the transition processes of entry into, and recovery from, inactivation with the time constants of several seconds as well as a few milliseconds. Voltage measurements under current-clamp showed that the threshold for action potential firing can be affected by the change of Na^+ current due to the inactivation. The multiple time scales of Na^+ channel inactivation are thought to contribute to history-dependent spike firings in retinal ganglion cells. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Retinal neuron / History-dependent / Na^+ channel / Inactivation / Action potential firing |
| Paper # | MBE2010-80 |
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| Committee | MBE |
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| Conference Date | 2011/1/20(1days) |
| Place (in Japanese) | (See Japanese page) |
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| Topics (in Japanese) | (See Japanese page) |
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| Paper Information | |
| Registration To | ME and Bio Cybernetics (MBE) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Slow-inactivation of voltage-gated Na^+ current and spike firing in rat retinal neurons |
| Sub Title (in English) | |
| Keyword(1) | Retinal neuron |
| Keyword(2) | History-dependent |
| Keyword(3) | Na^+ channel |
| Keyword(4) | Inactivation |
| Keyword(5) | Action potential firing |
| 1st Author's Name | Sho HARABE |
| 1st Author's Affiliation | Department of Human and Environmental Informatics, Graduate school of Science and Technology, Kumamoto University() |
| 2nd Author's Name | Tamami MOTOMURA |
| 2nd Author's Affiliation | Department of Human and Environmental Informatics, Graduate school of Science and Technology, Kumamoto University |
| 3rd Author's Name | Yuki HAYASHIDA |
| 3rd Author's Affiliation | Department of Human and Environmental Informatics, Graduate school of Science and Technology, Kumamoto University |
| 4th Author's Name | Nobuki MURAYAMA |
| 4th Author's Affiliation | Department of Human and Environmental Informatics, Graduate school of Science and Technology, Kumamoto University |
| Date | 2011-01-27 |
| Paper # | MBE2010-80 |
| Volume (vol) | vol.110 |
| Number (no) | 399 |
| Page | pp.pp.- |
| #Pages | 4 |
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