| Presentation | 2010/11/11 Cortical Mechanism Underlying Self-Initiation of Voluntary Movements : A New Behavioral and Electrophysiological Approach Yoshikazu ISOMURA, |
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| PDF Download Page | PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | Neurons in the motor cortex are activated at a variety of timing during self-initiated voluntary movement. However, how excitatory and inhibitory neurons participate in organizing the voluntary movement has been poorly understood. We performed juxtacellular recording and multi-neuron recording from the motor cortex of actively behaving rats to demonstrate different functional activations of excitatory pyramidal cells and inhibitory fast-spiking (FS) interneurons. Across cortical layers, pyramidal cells were activated diversely for sequential motor phases (e.g., preparation, initiation, execution), whereas FS interneurons were recruited predominantly for motor execution. Thus, FS interneurons may underlie command shaping, rather than command gating. Furthermore, our cross-correlation analysis of multi-neuron activity suggested that some of pyramidal cells discharged synchronously with similar and different functional classes of neurons through direct (or indirect) synaptic connections. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Operant Motor Task / Rat Motor Cortex / Multi-Neuron Recording / Juxtacellular Recording |
| Paper # | NC2010-56 |
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| Conference Information | |
| Committee | NC |
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| Conference Date | 2010/11/11(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
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| Paper Information | |
| Registration To | Neurocomputing (NC) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Cortical Mechanism Underlying Self-Initiation of Voluntary Movements : A New Behavioral and Electrophysiological Approach |
| Sub Title (in English) | |
| Keyword(1) | Operant Motor Task |
| Keyword(2) | Rat Motor Cortex |
| Keyword(3) | Multi-Neuron Recording |
| Keyword(4) | Juxtacellular Recording |
| 1st Author's Name | Yoshikazu ISOMURA |
| 1st Author's Affiliation | Brain Science Institute, Tamagawa University() |
| Date | 2010/11/11 |
| Paper # | NC2010-56 |
| Volume (vol) | vol.110 |
| Number (no) | 295 |
| Page | pp.pp.- |
| #Pages | 3 |
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