| Presentation | 2010-03-10 A Study on Path Following of Label-Permuted Solution for Support Vector Machine and Its Application for Microarray Data Analysis Yuta ISHIKAWA, Kota ISOBE, Ichiro TAKEUCHI, |
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| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | Microarray technology enables us to measure expression levels of thousands of genes simultaneously. The fundamental task of microarray data analysis is to find differentially expressed genes between two samples. In this study we consider how to find differentially expressed gene sets (rather than individual genes) between two samples. This task is called gene set analysis and it is mathematically formulated as multivariate two-sample test. As an approach of gene set analysis, we introduce a multivariate two-sample test whose test statistic is given by the classification error of support vector machine (SVM) classifier. The null distribution of the statistic is computed based on label permutation operation, and thus we need to train many SVM classifiers for permuted labels. In this paper we are concerned with the problem of reducing the computational cost of this operation by proposing a path-following algorithm to compute the path of label-permuted SVM classifiers. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Support Vector Machine / Path Following / Label-Permutation / Microarray / GSEA |
| Paper # | NC2009-132 |
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| Conference Information | |
| Committee | NC |
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| Conference Date | 2010/3/2(1days) |
| Place (in Japanese) | (See Japanese page) |
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| Topics (in Japanese) | (See Japanese page) |
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| Registration To | Neurocomputing (NC) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | A Study on Path Following of Label-Permuted Solution for Support Vector Machine and Its Application for Microarray Data Analysis |
| Sub Title (in English) | |
| Keyword(1) | Support Vector Machine |
| Keyword(2) | Path Following |
| Keyword(3) | Label-Permutation |
| Keyword(4) | Microarray |
| Keyword(5) | GSEA |
| 1st Author's Name | Yuta ISHIKAWA |
| 1st Author's Affiliation | Nagoya Institute of Technology() |
| 2nd Author's Name | Kota ISOBE |
| 2nd Author's Affiliation | Nagoya Institute of Technology |
| 3rd Author's Name | Ichiro TAKEUCHI |
| 3rd Author's Affiliation | Nagoya Institute of Technology |
| Date | 2010-03-10 |
| Paper # | NC2009-132 |
| Volume (vol) | vol.109 |
| Number (no) | 461 |
| Page | pp.pp.- |
| #Pages | 6 |
| Date of Issue | |