| Presentation | 2009-12-21 On the Pacemaker Activities of Cardiac Sinoatrial Node Cells Zhenxing PAN, Shinji DOI, |
|---|---|
| PDF Download Page |  PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | A sinoatrial node (cardiac pacemaker) cell generates an electrical signal (action potential) spontaneously and periodically, to make persistent contractions and relaxations of heart. The pacemaker activity of sinoatrial node cell is deeply related to various ion channels in its cell membrane. Since the abnormalities of ion channels cause serious arrhythmia, this paper uses the Zhang model of sinoatrial node cells to investigate the relation between rhythm (frequency of action potential generation) and ion channels. The Zhang model is described by the Hodgkin-Huxley-type nonlinear ordinary differential equations, are different between the regions (periphery or center) of sinoatrial node. We analyze the bifurcation structure of the Zhang model, and investigate the variability of rhythm and its sensitivity on ion channel conductances for different regions. Moreover, these results are also compared to those of another sinoatrial node cell model (Yanagihara-Noma-Irisawa model). The above results are expected to be useful in the treatment of arrhythmia. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | cardiac pacemaker / sinoatrial node cell / ionic channel / Zhang model / bifurcation structure / drug sensitivity |
| Paper # | NLP2009-139 |
| Date of Issue |
| Conference Information | |
| Committee | NLP |
|---|---|
| Conference Date | 2009/12/14(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | |
| Chair | |
| Vice Chair | |
| Secretary | |
| Assistant | |
| Paper Information | |
| Registration To | Nonlinear Problems (NLP) |
|---|---|
| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | On the Pacemaker Activities of Cardiac Sinoatrial Node Cells |
| Sub Title (in English) | |
| Keyword(1) | cardiac pacemaker |
| Keyword(2) | sinoatrial node cell |
| Keyword(3) | ionic channel |
| Keyword(4) | Zhang model |
| Keyword(5) | bifurcation structure |
| Keyword(6) | drug sensitivity |
| 1st Author's Name | Zhenxing PAN |
| 1st Author's Affiliation | Division of Electrical, Electronic and Information Engineering, Graduate School of Engineering, Osaka University() |
| 2nd Author's Name | Shinji DOI |
| 2nd Author's Affiliation | Department of Electrical Engineering, Graduate School of Engineering, Kyoto University |
| Date | 2009-12-21 |
| Paper # | NLP2009-139 |
| Volume (vol) | vol.109 |
| Number (no) | 354 |
| Page | pp.pp.- |
| #Pages | 6 |
| Date of Issue | |