| Presentation | 2009-03-10 Variability of Rhythms in a Cardiac Pacemaker Cell Model Zhenxing PAN, Rei YAMAGUCHI, Masato SENOO, Shinji DOI, |
|---|---|
| PDF Download Page |  PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | A heart repeats contraction and relaxation, and these motions are controlled by electrical stimuli (action potential). The electrical stimuli are generated in sinoatrial node (cardiac pacemaker) and propagated to whole heart. Since the abnormality of rhythm (frequency of action potential generation) in sinoatrial node causes serious arrhythmia such as tachycardia, it is necessary to analyze the variability of rhythms. The Yanagihara-Noma-Irisawa (YNI) model of sinoatrial-node cells is described by the Hodgkin-Huxley-type equations with seven variables. In this model, the characteristics of membrane potential and rhythm significantly depends on the variation of parameter. In this research, we focus mainly on the variability of rhythm and analyze the global bifurcation structure of the YNI model by varying the conductances of ionic channels. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | cardiac pacemaker cell / sinoatrial node / ionic channel / Yanagihara-Noma-Irisawa model / bifurcation structure / drug sensitivity |
| Paper # | NLP2008-160 |
| Date of Issue |
| Conference Information | |
| Committee | NLP |
|---|---|
| Conference Date | 2009/3/3(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | |
| Chair | |
| Vice Chair | |
| Secretary | |
| Assistant | |
| Paper Information | |
| Registration To | Nonlinear Problems (NLP) |
|---|---|
| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Variability of Rhythms in a Cardiac Pacemaker Cell Model |
| Sub Title (in English) | |
| Keyword(1) | cardiac pacemaker cell |
| Keyword(2) | sinoatrial node |
| Keyword(3) | ionic channel |
| Keyword(4) | Yanagihara-Noma-Irisawa model |
| Keyword(5) | bifurcation structure |
| Keyword(6) | drug sensitivity |
| 1st Author's Name | Zhenxing PAN |
| 1st Author's Affiliation | Division of Electrical, Electronic and Information Engineering, Graduate School of Engineering, Osaka University() |
| 2nd Author's Name | Rei YAMAGUCHI |
| 2nd Author's Affiliation | Division of Electrical, Electronic and Information Engineering, Graduate School of Engineering, Osaka University |
| 3rd Author's Name | Masato SENOO |
| 3rd Author's Affiliation | Division of Electrical, Electronic and Information Engineering, Graduate School of Engineering, Osaka University |
| 4th Author's Name | Shinji DOI |
| 4th Author's Affiliation | Division of Electrical, Electronic and Information Engineering, Graduate School of Engineering, Osaka University |
| Date | 2009-03-10 |
| Paper # | NLP2008-160 |
| Volume (vol) | vol.108 |
| Number (no) | 477 |
| Page | pp.pp.- |
| #Pages | 6 |
| Date of Issue | |