| Presentation | 2009-01-19 Progress Curve Analysis of Multisite Phosphorylation Using Michaelis-Menten Equation Yumi NAKAGAWA, Hideyuki CATEAU, |
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| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | Cooperativity in multisite phosphorylation that is an enhancement or a suppression of phosphorylation at some site due to phosphorylation at another site(s) is frequently observed We show that progress curve analysis with temporal information on the reaction obtained by integrating Michaelis-Menten(M-M) equations is useful to analyze such cooperativity. In this paper, we reveal strong universality of the internal time representation. Degradation of an enzyme may largely deforms a progress curve of a reaction. We show that progress curves of multisite phosphorylation, which are expressed in an internal time representation, are unchanged by the degradation. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Multisite Phosphorylation / Progress Curve / Cooperativity / Michaelis-Menten Equation |
| Paper # | NC2008-93 |
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| Conference Information | |
| Committee | NC |
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| Conference Date | 2009/1/12(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
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| Registration To | Neurocomputing (NC) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Progress Curve Analysis of Multisite Phosphorylation Using Michaelis-Menten Equation |
| Sub Title (in English) | |
| Keyword(1) | Multisite Phosphorylation |
| Keyword(2) | Progress Curve |
| Keyword(3) | Cooperativity |
| Keyword(4) | Michaelis-Menten Equation |
| 1st Author's Name | Yumi NAKAGAWA |
| 1st Author's Affiliation | Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology() |
| 2nd Author's Name | Hideyuki CATEAU |
| 2nd Author's Affiliation | Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology:RIKEN BSI-TOYOTA Collaboration Center |
| Date | 2009-01-19 |
| Paper # | NC2008-93 |
| Volume (vol) | vol.108 |
| Number (no) | 383 |
| Page | pp.pp.- |
| #Pages | 5 |
| Date of Issue | |