| Presentation | 2009-01-24 Computational analyses on optimization of the extracellular current stimuli delivered to neurons Katsuki TAMANAHA, Yuki HAYASHIDA, Nobuki MURAYAMA, |
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| PDF Download Page |  PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | For neural diseases, clinical trials of the treatments/prostheses with the functional electric stimulation have been widely performed in recent years. In those cases, it is critical to use the minimum amounts of current/charge to stimulate the target neurons, in order to guarantee their safety. However, the wave form, which is used as electric stimulation to clinical, is simple rectangular wave pulse and is not optimal about its amounts of current, wave form and position of stimulus. Therefore, in this study, we analyzed quantitatively on the optimization of electrical stimulus at the single neuron level by computer simulation used biophysics models of neurons. As a result, it was shown that the amounts of current/charge required for evoking spike firings of the model cells can be reduced by optimally adjusting the parameters of stimulation pulse waveforms, and that it was very more important to select the three dimensional position of the stimulation electrode optimally. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | neural prosthesis / electrical stimulation / neuron / biophysics model / computer simulation |
| Paper # | MBE2008-94 |
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| Conference Information | |
| Committee | MBE |
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| Conference Date | 2009/1/16(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
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| Paper Information | |
| Registration To | ME and Bio Cybernetics (MBE) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Computational analyses on optimization of the extracellular current stimuli delivered to neurons |
| Sub Title (in English) | |
| Keyword(1) | neural prosthesis |
| Keyword(2) | electrical stimulation |
| Keyword(3) | neuron |
| Keyword(4) | biophysics model |
| Keyword(5) | computer simulation |
| 1st Author's Name | Katsuki TAMANAHA |
| 1st Author's Affiliation | Graduate school of Science and Technology, Kumamoto University() |
| 2nd Author's Name | Yuki HAYASHIDA |
| 2nd Author's Affiliation | Graduate school of Science and Technology, Kumamoto University |
| 3rd Author's Name | Nobuki MURAYAMA |
| 3rd Author's Affiliation | Graduate school of Science and Technology, Kumamoto University |
| Date | 2009-01-24 |
| Paper # | MBE2008-94 |
| Volume (vol) | vol.108 |
| Number (no) | 405 |
| Page | pp.pp.- |
| #Pages | 4 |
| Date of Issue | |