| Presentation | 2008-11-21 Effects of aldose reductase inhibitor on peripheral sympathetic activity in the sciatic nerve of type 1 diabetic model rat Toru KARIMATA, Go SHINZAWA, Daisuke SATO, Takahiro OKAWA, Yasutomo NOMURA, Masataka KUSUNOKI, Takao NAKAMURA, |
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| PDF Download Page |  PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | Storeptozotoshin (STZ) was administered to rats of 8 weeks of age (type 1 diabetes models (STZ) group). Aldose reductase inhibitor (ARI) was orally administered for three weeks (STZ+ARI group) to improve the diabetic neuropathy via the polyol pathway. The glucose was administered through the jugular vein of anesthetized rats after the sympathetic nerve signal in the sciatic nerve was microneurographically derived, and the change in the sympathetic nerve activity before and after the administration was evaluated using action potential (AP) rate. The results showed that the change in AP rate was small in STZ group whereas AP rate was increased in the normal rats, and that in the STZ+ARI group was in between the normal and STZ groups. The results suggests that the functional deterioration of the sympathetic nerve system was induced with STZ and improved by ARI to some degree. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | aldose reductase / glucose metabolism / sympathetic nerve |
| Paper # | MBE2008-65 |
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| Conference Information | |
| Committee | MBE |
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| Conference Date | 2008/11/14(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | |
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| Vice Chair | |
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| Paper Information | |
| Registration To | ME and Bio Cybernetics (MBE) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Effects of aldose reductase inhibitor on peripheral sympathetic activity in the sciatic nerve of type 1 diabetic model rat |
| Sub Title (in English) | |
| Keyword(1) | aldose reductase |
| Keyword(2) | glucose metabolism |
| Keyword(3) | sympathetic nerve |
| 1st Author's Name | Toru KARIMATA |
| 1st Author's Affiliation | Department of Environmental Life Science, Graduate School Medical Science, Yamagata University() |
| 2nd Author's Name | Go SHINZAWA |
| 2nd Author's Affiliation | Department of Environmental Life Science, Graduate School Medical Science, Yamagata University |
| 3rd Author's Name | Daisuke SATO |
| 3rd Author's Affiliation | Department of Environmental Life Science, Graduate School Medical Science, Yamagata University |
| 4th Author's Name | Takahiro OKAWA |
| 4th Author's Affiliation | Department of Bio-system engineering, Faculty of engineering, Yamagata University |
| 5th Author's Name | Yasutomo NOMURA |
| 5th Author's Affiliation | Department of Environmental Life Science, Graduate School Medical Science, Yamagata University |
| 6th Author's Name | Masataka KUSUNOKI |
| 6th Author's Affiliation | Department of Internal Medicine, Aichi Medical University Medical Clinic |
| 7th Author's Name | Takao NAKAMURA |
| 7th Author's Affiliation | Department of Environmental Life Science, Graduate School Medical Science, Yamagata University |
| Date | 2008-11-21 |
| Paper # | MBE2008-65 |
| Volume (vol) | vol.108 |
| Number (no) | 314 |
| Page | pp.pp.- |
| #Pages | 4 |
| Date of Issue | |