| Presentation | 2008-03-13 k shortest path analysis of hippocampal signal transduction change by Alzheimer's gene regulations Ryoji YANASHIMA, Yoshiya MATSUBARA, Noriyuki KITAGAWA, Shinichi KIKUCHI, Kotaro OKA, Masaru TOMITA, |
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| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | Alzheimer's disease (AD) has been studied for the changes of molecules such as amyloid β. Few studies have investigated the change of the whole signal transduction system, preventing the elucidation of the mechanism. We aimed to elucidate the structural features of human hippocampal signal transduction system and the rules and mechanisms which emerge in AD. We constructed AD specific signal transduction network as a graph using gene expression and weighted directed signal transduction pathway data of hippocampus, and evaluated the changes of the system by commonly used statistical indexes and k shortest path. As a result, although the network density, transitivity, average clustering coefficient and shortest path length in the AD network resembled those in the network, the nodes of which were removed randomly, the robustness differed in the specific input and output sets in the k shortest path analysis. Applying this model, we successfully identified the changes of robustness in human hippocampal signal transductions in AD due to the differential gene expressions. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Signal transduction / k shortest path / Gene regulations / Alzheimer's disease |
| Paper # | NC2007-154 |
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| Committee | NC |
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| Conference Date | 2008/3/5(1days) |
| Place (in Japanese) | (See Japanese page) |
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| Topics (in Japanese) | (See Japanese page) |
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| Registration To | Neurocomputing (NC) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | k shortest path analysis of hippocampal signal transduction change by Alzheimer's gene regulations |
| Sub Title (in English) | |
| Keyword(1) | Signal transduction |
| Keyword(2) | k shortest path |
| Keyword(3) | Gene regulations |
| Keyword(4) | Alzheimer's disease |
| 1st Author's Name | Ryoji YANASHIMA |
| 1st Author's Affiliation | Institute for Advanced Biosciences, Keio University() |
| 2nd Author's Name | Yoshiya MATSUBARA |
| 2nd Author's Affiliation | Institute for Advanced Biosciences, Keio University |
| 3rd Author's Name | Noriyuki KITAGAWA |
| 3rd Author's Affiliation | Institute for Advanced Biosciences, Keio University |
| 4th Author's Name | Shinichi KIKUCHI |
| 4th Author's Affiliation | Institute for Advanced Biosciences, Keio University |
| 5th Author's Name | Kotaro OKA |
| 5th Author's Affiliation | Department of Biosciences and Informatics Faculty of Science and Technology, Keio University |
| 6th Author's Name | Masaru TOMITA |
| 6th Author's Affiliation | Institute for Advanced Biosciences, Keio University |
| Date | 2008-03-13 |
| Paper # | NC2007-154 |
| Volume (vol) | vol.107 |
| Number (no) | 542 |
| Page | pp.pp.- |
| #Pages | 6 |
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