| Presentation | 2008-02-01 On the Global Bifurcation Structure of a Detailed Ventricular Myocardial Cell Model and Drug Sensitivity of Ionic Channels (II) Rei YAMAGUCHI, Satoru HISAKADO, Shinji DOI, Sadatoshi KUMAGAI, |
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| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | When an electrical stimulus is applied to a ventricular myocardial cell, ions move between inside and outside of the cell through ionic channels, and the membrane potential is varied. The Luo-Rudy dynamic model is one of detailed cardiac cell models which describe the temporal variation of cell membrane potential. This model is described by the Hodgkin-Huxley-type equations with 21 variables, and the membrane potential significantly depends on the variations of parameters. In this research, we vary the external stimulus current and the maximum conductances or parameters which play the same role as the maximum conductance, and analyze the global bifuacation structure of the model. Thus, we investigate the drug sensitivity of ionic channels and interactions between ionic channels. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | ionic channel / channelopathy / Luo-Rudy dynamic model / bifurcation structure / drug sensitivity |
| Paper # | NLP2007-151 |
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| Committee | NLP |
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| Conference Date | 2008/1/25(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
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| Paper Information | |
| Registration To | Nonlinear Problems (NLP) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | On the Global Bifurcation Structure of a Detailed Ventricular Myocardial Cell Model and Drug Sensitivity of Ionic Channels (II) |
| Sub Title (in English) | |
| Keyword(1) | ionic channel |
| Keyword(2) | channelopathy |
| Keyword(3) | Luo-Rudy dynamic model |
| Keyword(4) | bifurcation structure |
| Keyword(5) | drug sensitivity |
| 1st Author's Name | Rei YAMAGUCHI |
| 1st Author's Affiliation | Division of Electrical, Electronic and Information Engineering, Graduate School of Engineering, Osaka University() |
| 2nd Author's Name | Satoru HISAKADO |
| 2nd Author's Affiliation | Division of Electrical, Electronic and Information Engineering, Graduate School of Engineering, Osaka University |
| 3rd Author's Name | Shinji DOI |
| 3rd Author's Affiliation | Division of Electrical, Electronic and Information Engineering, Graduate School of Engineering, Osaka University |
| 4th Author's Name | Sadatoshi KUMAGAI |
| 4th Author's Affiliation | Division of Electrical, Electronic and Information Engineering, Graduate School of Engineering, Osaka University |
| Date | 2008-02-01 |
| Paper # | NLP2007-151 |
| Volume (vol) | vol.107 |
| Number (no) | 478 |
| Page | pp.pp.- |
| #Pages | 6 |
| Date of Issue | |