| Presentation | 2007-08-10 Protective Mechanism of the Inner Ear from Traumatic Noise Exposure Actuated by Heat Stress Michio MURAKOSHI, Naohiro YOSHIDA, Yoko KITSUNAI, Koji IIDA, Shun KUMANO, Takashi SUZUKI, Toshimitsu KOBAYASHI, Hiroshi WADA, |
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| PDF Download Page |  PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | Noise-induced hearing loss was reported to be decreased by raising the body temperature before traumatic noise exposure, i.e., heat stress. However, the protective mechanism of the inner ear against such traumatic exposure remains unknown. In the present study, the mechanical properties and the amount of filamentous actin of outer hair cells (OHCs) in mice with or without heat stress were measured by atomic force microscopy and confocal laser scanning microscopy, respectively. The conditioning by heat stress caused an increase in F-actin of the OHCs, leading to an increase in their Young's modulus. These results suggest that OHCs exposed to prior heat stress possibly experience less strain when they are exposed to loud noise, resulting in protection from traumatic noise exposure. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Heat Stress / Outer Hair Cell / Young's Modulus / Filamentous Actin / Prestin / Heat Shock Protein / Distortion Product Otoacoustic Emission / Atomic Force Microscopy / Confocal Laser Scanning Microscopy |
| Paper # | EA2007-49 |
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| Conference Information | |
| Committee | EA |
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| Conference Date | 2007/8/3(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
| Topics (in English) | |
| Chair | |
| Vice Chair | |
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| Paper Information | |
| Registration To | Engineering Acoustics (EA) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Protective Mechanism of the Inner Ear from Traumatic Noise Exposure Actuated by Heat Stress |
| Sub Title (in English) | |
| Keyword(1) | Heat Stress |
| Keyword(2) | Outer Hair Cell |
| Keyword(3) | Young's Modulus |
| Keyword(4) | Filamentous Actin |
| Keyword(5) | Prestin |
| Keyword(6) | Heat Shock Protein |
| Keyword(7) | Distortion Product Otoacoustic Emission |
| Keyword(8) | Atomic Force Microscopy |
| Keyword(9) | Confocal Laser Scanning Microscopy |
| 1st Author's Name | Michio MURAKOSHI |
| 1st Author's Affiliation | Graduate School of Engineering, Tohoku University() |
| 2nd Author's Name | Naohiro YOSHIDA |
| 2nd Author's Affiliation | Graduate School of Medicine, Tohoku University |
| 3rd Author's Name | Yoko KITSUNAI |
| 3rd Author's Affiliation | Graduate School of Engineering, Tohoku University |
| 4th Author's Name | Koji IIDA |
| 4th Author's Affiliation | Graduate School of Engineering, Tohoku University |
| 5th Author's Name | Shun KUMANO |
| 5th Author's Affiliation | Graduate School of Engineering, Tohoku University |
| 6th Author's Name | Takashi SUZUKI |
| 6th Author's Affiliation | Graduate School of Engineering, Tohoku University |
| 7th Author's Name | Toshimitsu KOBAYASHI |
| 7th Author's Affiliation | Graduate School of Medicine, Tohoku University |
| 8th Author's Name | Hiroshi WADA |
| 8th Author's Affiliation | Graduate School of Engineering, Tohoku University |
| Date | 2007-08-10 |
| Paper # | EA2007-49 |
| Volume (vol) | vol.107 |
| Number (no) | 187 |
| Page | pp.pp.- |
| #Pages | 6 |
| Date of Issue | |