| Presentation | 2007-06-14 A Study on Significance Analysis of Gene Sets Using Nearest-Neighbor Classification Error Ichiro TAKEUCHI, Shintaro HAYASHI, Miyuki SUGURO, Masao SETO, |
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| PDF Download Page |  PDF download Page Link |
| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | Relating gene expression profiles from microarray experiments with biological knowledge databases is an important step for understanding biological mechanism. It motivates the development of statistical techniques that quantify the significance of the expression profiles for sets of genes defined, e.g., based on pathway information. In this report we propose a new approach for gene set significance analysis. The proposed test measures the significance of gene sets using cross-validated errors of nearest-neighbor classifiers. Our approach is computationally efficient and powerful to detect various types of differences in expression patterns. We demonstrate the advantage of our approach through the simulation studies for power analysis and an application to a public microarray data. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Microarray / Expression Profile / Pathway Analysis / Gene Set / Statistical Test / Multiple Comparison / Permutation Test / Nearest-Neighbor Method / Cross-Validation |
| Paper # | NC2007-13 |
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| Conference Information | |
| Committee | NC |
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| Conference Date | 2007/6/7(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
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| Paper Information | |
| Registration To | Neurocomputing (NC) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | A Study on Significance Analysis of Gene Sets Using Nearest-Neighbor Classification Error |
| Sub Title (in English) | |
| Keyword(1) | Microarray |
| Keyword(2) | Expression Profile |
| Keyword(3) | Pathway Analysis |
| Keyword(4) | Gene Set |
| Keyword(5) | Statistical Test |
| Keyword(6) | Multiple Comparison |
| Keyword(7) | Permutation Test |
| Keyword(8) | Nearest-Neighbor Method |
| Keyword(9) | Cross-Validation |
| 1st Author's Name | Ichiro TAKEUCHI |
| 1st Author's Affiliation | Division of Information Engineering, Graduate School of Engineering, Mie University() |
| 2nd Author's Name | Shintaro HAYASHI |
| 2nd Author's Affiliation | Division of Information Engineering, Graduate School of Engineering, Mie University |
| 3rd Author's Name | Miyuki SUGURO |
| 3rd Author's Affiliation | Division of Molecular Medicine, Aich Cancer Center Research Institute |
| 4th Author's Name | Masao SETO |
| 4th Author's Affiliation | Division of Molecular Medicine, Aich Cancer Center Research Institute |
| Date | 2007-06-14 |
| Paper # | NC2007-13 |
| Volume (vol) | vol.107 |
| Number (no) | 92 |
| Page | pp.pp.- |
| #Pages | 6 |
| Date of Issue | |