| Presentation | 2007-06-14 Optical imaging of dendritic propagating potential in heterosynaptic associative LTP of rat hippocampal CA1 pyramidal neurons Makoto Yoneyama, Yasuhiro Fukushima, Minoru Tsukada, |
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| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | In contrast to Hebb type learning rule, in spatiotemporal learning rule (STLR) proposed by Tsukada et al. (1996), synaptic strength is modified by both spatial coincidence and the temporal summation of synaptic inputs without back propagating action potential (BPAP). When a pair of strong and weak stimulation is applied simultaneously in hippocampal CA1, heterosynaptic associative LTP, one of the physiological evidence of STLR, is induced in both stimulation sites. Our previous study showed that heterosynaptic associative LTP could be induced under decreased-BPAPs condition using low TTX application. However, the mechanism of LTP was unclear. In this study, we recorded dynamic responses in both strong and weak input site under low TTX condition by using voltage-sensitive dye. From this result, it is clear that EPSP produced by strong stimulation propagates along the dendrite and affects the synaptic strength of weak input site. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Hippocampus / Optical Imaging / Spatiotemporal learning rule / heterosynaptic associative LTP |
| Paper # | NC2007-12 |
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| Committee | NC |
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| Conference Date | 2007/6/7(1days) |
| Place (in Japanese) | (See Japanese page) |
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| Topics (in Japanese) | (See Japanese page) |
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| Registration To | Neurocomputing (NC) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Optical imaging of dendritic propagating potential in heterosynaptic associative LTP of rat hippocampal CA1 pyramidal neurons |
| Sub Title (in English) | |
| Keyword(1) | Hippocampus |
| Keyword(2) | Optical Imaging |
| Keyword(3) | Spatiotemporal learning rule |
| Keyword(4) | heterosynaptic associative LTP |
| 1st Author's Name | Makoto Yoneyama |
| 1st Author's Affiliation | Graduate School of Engineering Tamagawa University() |
| 2nd Author's Name | Yasuhiro Fukushima |
| 2nd Author's Affiliation | Research Institute Tamagawa University |
| 3rd Author's Name | Minoru Tsukada |
| 3rd Author's Affiliation | Research Institute Tamagawa University |
| Date | 2007-06-14 |
| Paper # | NC2007-12 |
| Volume (vol) | vol.107 |
| Number (no) | 92 |
| Page | pp.pp.- |
| #Pages | 5 |
| Date of Issue | |