Presentation | 2007-03-14 Estimation of Specific Membrane Resistance in Distal Dendrite Using Neuronal Response to Perturbation Toshiaki OMORI, Toru AONISHI, Hiroyoshi MIYAKAWA, Masashi INOUE, Masato OKADA, |
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Abstract(in Japanese) | (See Japanese page) |
Abstract(in English) | Non-uniform membrane property in dendrite is one of important determinants for manner of information integration in neurons, and therefore its distribution is important for information processings in brain. It is known that in the distal dendrite, many synaptic inputs are received and important information processings such as synaptic plasticity are performed. However, membrane property in distal dendrite is unclear since its direct measurements are difficult. To estimate membrane property in distal dendrite, we performed numerical simulation of membrane responses to perturbation to single neuron, using compartment model with non-uniformity of membrane property, and we compared numerical results with those observed in the hippocampal CA1 slices using optical recordings. Estimated membrane resistance at distal dendrite is lower than that at proximal dendrite and it was suggested that there is a steep decrease in the passive membrane property between distal and proximal dendrites. |
Keyword(in Japanese) | (See Japanese page) |
Keyword(in English) | distal dendrite / specific membrane resistance / synaptic integration / compartment model |
Paper # | NC2006-122 |
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Conference Information | |
Committee | NC |
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Conference Date | 2007/3/7(1days) |
Place (in Japanese) | (See Japanese page) |
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Paper Information | |
Registration To | Neurocomputing (NC) |
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Language | JPN |
Title (in Japanese) | (See Japanese page) |
Sub Title (in Japanese) | (See Japanese page) |
Title (in English) | Estimation of Specific Membrane Resistance in Distal Dendrite Using Neuronal Response to Perturbation |
Sub Title (in English) | |
Keyword(1) | distal dendrite |
Keyword(2) | specific membrane resistance |
Keyword(3) | synaptic integration |
Keyword(4) | compartment model |
1st Author's Name | Toshiaki OMORI |
1st Author's Affiliation | JSPS:Brain Science Institute, RIKEN() |
2nd Author's Name | Toru AONISHI |
2nd Author's Affiliation | Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology:Brain Science Institute, RIKEN |
3rd Author's Name | Hiroyoshi MIYAKAWA |
3rd Author's Affiliation | School of Life Science, Tokyo University of Pharmacy and Life Science |
4th Author's Name | Masashi INOUE |
4th Author's Affiliation | School of Life Science, Tokyo University of Pharmacy and Life Science |
5th Author's Name | Masato OKADA |
5th Author's Affiliation | Graduate School of Frontier Sciences, The University of Tokyo:Brain Science Institute, RIKEN |
Date | 2007-03-14 |
Paper # | NC2006-122 |
Volume (vol) | vol.106 |
Number (no) | 588 |
Page | pp.pp.- |
#Pages | 6 |
Date of Issue |