| Presentation | 2007-01-25 Improvement of Dendritic Signal Transfer Due to Steep Change of Specific Membrane Resistance Toshiaki OMORI, Toru AONISHI, Masato OKADA, |
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| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | Dendrites of hippocampal CA1 pyramidal neurons receive synaptic inputs from the entorhinal cortex (EC) and hippocampal CA3, and these two kinds of synaptic inputs are received separately in those dendrites; inputs from the EC are received at distal dendrite, whereas those from the CA3 are received at proximal dendrite. It has been suggested that it is difficult to induce somatic firing just with synaptic inputs to distal dendrite. In previous studies, Omori et al. estimated that distribution of specific membrane resistance, one of passive membrane properties, obeys step function; specific membrane resistance in distal dendrite is relatively small compared with that in proximal dendrite. By analysis of cable equation and numerical simulation of compartment model, we show that signal transfer from distal dendrite to soma is significantly improved due to non-uniformity of the specific membrane resistance obeying step function. Our results suggest that somatic firing can be induced even just with synaptic inputs to distal dendrite by the estimated non-uniform distribution of specific membrane resistance. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | dendrite / signal transfer / non-uniform membrane property / cable equation / compartment model / hippocampus |
| Paper # | NC2006-95 |
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| Conference Information | |
| Committee | NC |
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| Conference Date | 2007/1/18(1days) |
| Place (in Japanese) | (See Japanese page) |
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| Topics (in Japanese) | (See Japanese page) |
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| Registration To | Neurocomputing (NC) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Improvement of Dendritic Signal Transfer Due to Steep Change of Specific Membrane Resistance |
| Sub Title (in English) | |
| Keyword(1) | dendrite |
| Keyword(2) | signal transfer |
| Keyword(3) | non-uniform membrane property |
| Keyword(4) | cable equation |
| Keyword(5) | compartment model |
| Keyword(6) | hippocampus |
| 1st Author's Name | Toshiaki OMORI |
| 1st Author's Affiliation | RIKEN Brain Science Institute:JSPS Research Fellow() |
| 2nd Author's Name | Toru AONISHI |
| 2nd Author's Affiliation | Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology:RIKEN Brain Science Institute |
| 3rd Author's Name | Masato OKADA |
| 3rd Author's Affiliation | Graduate School of Frontier Sciences, The University of Tokyo Transdisciplinary Sciences Bldg:RIKEN Brain Science Institute |
| Date | 2007-01-25 |
| Paper # | NC2006-95 |
| Volume (vol) | vol.106 |
| Number (no) | 500 |
| Page | pp.pp.- |
| #Pages | 6 |
| Date of Issue | |