| Presentation | 2006-11-10 The frequency of carbachol-induced β-oscillation is increased by the activation of adrenergic receptor in rat hippocampal slices Masafumi NAKANO, Jun ARAI, Kiyohisa NATSUME, |
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| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | β rhythm in hippocampus has not so far been studied while θ rhythm was studied by many researchers in terms of the relationship with the memory function. In olfactory learning, β rhythm is said to be related to the retrieval process of the memory processing. Recently it is found that locus ceruleus (LC) activation suppresses β rhythm in dentate gyrus of hippocampus in vivo. Noradrenergic fibers derived from LC project to hippocampus. Carbachol, a cholinergic agent, can induce β-oscillation in rat hippocampal slices like β rhythm in vivo. In the present study, the effect of noradrenaline (NA) on the generation of carbachol-induced β-oscillation was studied in CA3 region of rat hippocampal slices. Carbachol (30μM) induced β-oscillation with the frequency and the amplitude of 15.6±0.3Hz, and 0.7±0.1 mV, respectively (mean±S.E.M.; n=24). NA(50μM) significantly increased the frequency of 16.7±0.4Hz (p<0.05), not change the amplitude. The results suggest that LC activation may increase the frequency of β rhythm in CA3 region of hippocampus. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Carbachol / Noradrenaline / Hippocampal Slices |
| Paper # | NC2006-59 |
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| Conference Information | |
| Committee | NC |
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| Conference Date | 2006/11/3(1days) |
| Place (in Japanese) | (See Japanese page) |
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| Topics (in Japanese) | (See Japanese page) |
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| Registration To | Neurocomputing (NC) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | The frequency of carbachol-induced β-oscillation is increased by the activation of adrenergic receptor in rat hippocampal slices |
| Sub Title (in English) | |
| Keyword(1) | Carbachol |
| Keyword(2) | Noradrenaline |
| Keyword(3) | Hippocampal Slices |
| 1st Author's Name | Masafumi NAKANO |
| 1st Author's Affiliation | Graduate School of Life Science and System Engineering, Kyushu Institute of technology() |
| 2nd Author's Name | Jun ARAI |
| 2nd Author's Affiliation | Graduate School of Life Science and System Engineering, Kyushu Institute of technology |
| 3rd Author's Name | Kiyohisa NATSUME |
| 3rd Author's Affiliation | Graduate School of Life Science and System Engineering, Kyushu Institute of technology |
| Date | 2006-11-10 |
| Paper # | NC2006-59 |
| Volume (vol) | vol.106 |
| Number (no) | 341 |
| Page | pp.pp.- |
| #Pages | 6 |
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