| Presentation | 2006-11-13 Omission of arterial blood sampling in PET neuroreceptor mapping using intersectional searching method : Improvement of the blood curve estimation using the selection of voxels base on singular values and the clustering Junichi Yano, Mika Naganawa, Masao Yanagisawa, Yuichi Kimura, |
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| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | In neuroreceptor imaging with PET, serial arterial blood sampling is required to obtain a time activity curve of radioactivities in blood. However, serial arterial blood sampling is required to be omitted, because it is an invasive and painful operation. In this paper, we propose a method for improving an estimation of a cumulative integrated plasma time-activity curve (cpTAC) using an intersectional searching algorithm. Estimation of the cpTAC is influenced by two factors: One is a selection of voxels used for the estimation and the other is noise included in actual PET data. Regarding the first factor, the second least singular value, which evaluates an extent of the estimation space, was adopted as a criterion for selecting voxels. Regarding the second factor, averaging filter was adapted and clustering was subsequently performed based on kinetics at each voxel in order to improve signal to noise ratio (SNR) of PET data. From the simulated results, the proposed criterion worked well only in case of the data with high SNR. In the actual PET data, the proposed criterion could not be useful in noise reducted data, because SNR at voxels is different from each other. However, the estimated cpTAC matched well with the measured cpTAC due to enough noise reduction. We concluded that our proposed method is useful in neuroreceptor imaging without serial arterial blood sampling. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | PET / intersectional searching algorithm / Logan plot / arterial blood sampling / clustering |
| Paper # | MI2006-72 |
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| Conference Information | |
| Committee | MI |
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| Conference Date | 2006/11/6(1days) |
| Place (in Japanese) | (See Japanese page) |
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| Topics (in Japanese) | (See Japanese page) |
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| Registration To | Medical Imaging (MI) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Omission of arterial blood sampling in PET neuroreceptor mapping using intersectional searching method : Improvement of the blood curve estimation using the selection of voxels base on singular values and the clustering |
| Sub Title (in English) | |
| Keyword(1) | PET |
| Keyword(2) | intersectional searching algorithm |
| Keyword(3) | Logan plot |
| Keyword(4) | arterial blood sampling |
| Keyword(5) | clustering |
| 1st Author's Name | Junichi Yano |
| 1st Author's Affiliation | Graduate School of Science and Engineering, Waseda University() |
| 2nd Author's Name | Mika Naganawa |
| 2nd Author's Affiliation | Japan Society for the Promotion of Science:Positron Medical Center, Tokyo Metropolitan Institute of Gerontology |
| 3rd Author's Name | Masao Yanagisawa |
| 3rd Author's Affiliation | Graduate School of Science and Engineering, Waseda University |
| 4th Author's Name | Yuichi Kimura |
| 4th Author's Affiliation | Positron Medical Center, Tokyo Metropolitan Institute of Gerontology |
| Date | 2006-11-13 |
| Paper # | MI2006-72 |
| Volume (vol) | vol.106 |
| Number (no) | 343 |
| Page | pp.pp.- |
| #Pages | 6 |
| Date of Issue | |