| Presentation | 2006-06-15 Drug-response prediction from microarray data using network-based de-noising Tsuyoshi KATO, Koh MIURA, Yukio MURATA, Kiyoshi ASAI, Paul B. HORTON, Wataru FUJIBUCHI, Koji TSUDA, |
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| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | Prediction of human cell response to anti-cancer drugs (compounds) from microarray data is a challenging problem, due to the noise properties of microarrays as well as the high variance of living cell responses to drugs. Hence there is a strong need for more practical and robust methods than standard methods for real-value prediction. We devised an extended version of the off-subspace noise-reduction (de-noising) method to incorporate heterogeneous network data such as sequence similarity or protein protein interactions into a single framework. Experimental results show that prediction performance is improved by combining a prediction method with our de-noising method. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | microarray data / anti-cancer drugs / network / off-subspace de-noising method |
| Paper # | NC2006-16 |
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| Conference Information | |
| Committee | NC |
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| Conference Date | 2006/6/8(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
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| Paper Information | |
| Registration To | Neurocomputing (NC) |
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| Language | ENG |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Drug-response prediction from microarray data using network-based de-noising |
| Sub Title (in English) | |
| Keyword(1) | microarray data |
| Keyword(2) | anti-cancer drugs |
| Keyword(3) | network |
| Keyword(4) | off-subspace de-noising method |
| 1st Author's Name | Tsuyoshi KATO |
| 1st Author's Affiliation | Graduate School of Frontier Sciences, The University of Tokyo() |
| 2nd Author's Name | Koh MIURA |
| 2nd Author's Affiliation | Division of Biological Regulation and Oncology, Department of Surgery, Tohoku University Graduate School of Medicine |
| 3rd Author's Name | Yukio MURATA |
| 3rd Author's Affiliation | Division of Biological Regulation and Oncology, Department of Surgery, Tohoku University Graduate School of Medicine |
| 4th Author's Name | Kiyoshi ASAI |
| 4th Author's Affiliation | Graduate School of Frontier Sciences, The University of Tokyo:AIST Computational Biology Research Center |
| 5th Author's Name | Paul B. HORTON |
| 5th Author's Affiliation | AIST Computational Biology Research Center |
| 6th Author's Name | Wataru FUJIBUCHI |
| 6th Author's Affiliation | AIST Computational Biology Research Center |
| 7th Author's Name | Koji TSUDA |
| 7th Author's Affiliation | AIST Computational Biology Research Center |
| Date | 2006-06-15 |
| Paper # | NC2006-16 |
| Volume (vol) | vol.106 |
| Number (no) | 101 |
| Page | pp.pp.- |
| #Pages | 6 |
| Date of Issue | |