Presentation 2006-03-15
BCM-type synaptic plasticity using the threshold as linear summation of calcium concentration
Hiroki KURASHIGE, Yutaka SAKAI,
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Abstract(in English) So far, changes in synaptic strength have been modeled as assuming that decided based on an absolute level of the calcium concentration. However, it has been pointed out not to be able to reproduce the properties of the spike-timing-dependent plasticity (STDP) by such a model. In this study, we present a model for synaptic plasticity based on the difference between the calcium inflow caused by pairing of presynaptic firing and postsynaptic firing and the linear summation of the calcium inflows caused by presynaptic firing and postsynaptic firing, and examine it by simulation experiment using NEURON simulator. It is shown that the timing property and the dependence on initial synaptic strength of STDP are reproduced using this model. In addition, we show that it is able to be important for the dependence on initial synaptic strength that NMDA conductance has some value even when AMPA conductance has the value of almost 0.
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Keyword(in English) STDP / calcium concentration / BCM rule / NMDA channel
Paper # NC2005-113
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Committee NC
Conference Date 2006/3/8(1days)
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Registration To Neurocomputing (NC)
Language JPN
Title (in Japanese) (See Japanese page)
Sub Title (in Japanese) (See Japanese page)
Title (in English) BCM-type synaptic plasticity using the threshold as linear summation of calcium concentration
Sub Title (in English)
Keyword(1) STDP
Keyword(2) calcium concentration
Keyword(3) BCM rule
Keyword(4) NMDA channel
1st Author's Name Hiroki KURASHIGE
1st Author's Affiliation Graduate school of Engineering, Tamagawa University()
2nd Author's Name Yutaka SAKAI
2nd Author's Affiliation Faculty of Engineering, Tamagawa University
Date 2006-03-15
Paper # NC2005-113
Volume (vol) vol.105
Number (no) 657
Page pp.pp.-
#Pages 6
Date of Issue