| Presentation | 2006-03-15 Filopodial elongation mechanism controled by actin filament in a neural growth cone Tomofumi FUKATA, Yuichi SAKUMURA, Kaoru KATOH, Shin ISHII, |
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| Abstract(in Japanese) | (See Japanese page) |
| Abstract(in English) | There exist many protrusions called filopodias at a neural axon terminal. Filopodial movements are driven by actin polymerization. The Elastic Brownian Ratchet (EBR) model and the Lock, Load, and Fire (LLF) model explain how actin filaments push the cell membrane. This study explores which is a more possible model by comparing the filopodial movements obtained from simulations with those from experimental images. Our simulation results suggest that a single actin filament is insufficient to reproduce the movement of real filopodia for both models. We also show that EBR model is superior to LLF model in reproducibility of experimental data and controllability of dynamic behaviors of growth cones. |
| Keyword(in Japanese) | (See Japanese page) |
| Keyword(in English) | Filopodia / Actin filament / Elastic brownian ratchet / Growth cone |
| Paper # | NC2005-112 |
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| Conference Information | |
| Committee | NC |
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| Conference Date | 2006/3/8(1days) |
| Place (in Japanese) | (See Japanese page) |
| Place (in English) | |
| Topics (in Japanese) | (See Japanese page) |
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| Paper Information | |
| Registration To | Neurocomputing (NC) |
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| Language | JPN |
| Title (in Japanese) | (See Japanese page) |
| Sub Title (in Japanese) | (See Japanese page) |
| Title (in English) | Filopodial elongation mechanism controled by actin filament in a neural growth cone |
| Sub Title (in English) | |
| Keyword(1) | Filopodia |
| Keyword(2) | Actin filament |
| Keyword(3) | Elastic brownian ratchet |
| Keyword(4) | Growth cone |
| 1st Author's Name | Tomofumi FUKATA |
| 1st Author's Affiliation | Graduate School of Information Science, Nara Institute of Science and Technology() |
| 2nd Author's Name | Yuichi SAKUMURA |
| 2nd Author's Affiliation | Graduate School of Information Science, Nara Institute of Science and Technology |
| 3rd Author's Name | Kaoru KATOH |
| 3rd Author's Affiliation | National Institute of Advanced Industrial Science and Technology Tsukuba Central |
| 4th Author's Name | Shin ISHII |
| 4th Author's Affiliation | Graduate School of Information Science, Nara Institute of Science and Technology |
| Date | 2006-03-15 |
| Paper # | NC2005-112 |
| Volume (vol) | vol.105 |
| Number (no) | 657 |
| Page | pp.pp.- |
| #Pages | 6 |
| Date of Issue | |